2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
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1609394-10-6
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- CAS №
- 1609394-10-6
- английское имя:
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- Синонимы:
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine;Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-;EOS-61512;Deucravacitinib Impurity 8;BMS-986165 Related Compound 3;2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline;2-methoxybenzyl carbamimidothioate hydrochloride;2-Methoxy-3-(1-methy-1H-1 ,2,4-triazol-3-yl)aniline;2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline;2-Methoxy-3-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenylamine
- CBNumber:
- CB23122644
- Формула:
- C10H12N4O
- молекулярный вес:
- 204.23
- MOL File:
- 1609394-10-6.mol
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2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline атрибут
| Температура кипения: |
437.6±55.0 °C(Predicted) |
| плотность: |
1.29±0.1 g/cm3(Predicted) |
| растворимость: |
DMSO (Slightly) |
| пка: |
3.45±0.10(Predicted) |
| форма: |
Solid |
| цвет: |
Pale Orange to Brown |
| InChI: |
InChI=1S/C10H12N4O/c1-14-6-12-10(13-14)7-4-3-5-8(11)9(7)15-2/h3-6H,11H2,1-2H3 |
| ИнЧИКей: |
FIAZRZSVFOMYSD-UHFFFAOYSA-N |
| SMILES: |
C1(N)=CC=CC(C2N=CN(C)N=2)=C1OC |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
| символ（GHS） |
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| сигнальное слово |
Danger |
| Заявление об опасности |
| пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
| H301+H311+H331 |
Токсично при проглатывании, при контакте с кожей или при
вдыхании. |
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| Внимание |
| P261 |
Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/
аэрозолей. |
| P280 |
Использовать перчатки/ средства защиты глаз/ лица. |
| P301+P310 |
ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за
медицинской помощью. Прополоскать рот. |
| P311 |
Обратиться за медицинской помощью. |
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2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline химические свойства, назначение, производство
Химические свойства
white solid
Использование
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases.
Синтез
To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg) were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C. 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline препаратная продукция и сырье
сырьё
препарат
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline поставщик
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