TALATISAMINE

A further atisine alkaloid, this base is found in Aconitum talassicum and forms colourless crystals from EtOH. It is optically inactive and yields crystalline salts with mineral acids, e.g. the hydrochloride, m.p. 195-6°C; hydro bromide dihydrate, m.p. 78-80°C; hydriodide trihydrate, m.p. 67.5-68.5°C; [α]_D- 12.8° (H20). The anhydrous form of the last salt decomposes at 130-1°C. The methiodide has m.p. 220-1°C and the alkaloid also yields a monoacetate, m.p. 97-8°C and the diacetate, m.p. 127-9°C; [α]_D - 5.05° (MeOH), indicating the presence of two hydroxyl groups in the molecule. The structure has been elucidated on the basis of the NMR spectra of the acetyl benzoyl derivative and two products of the pyrolysis of the diacetyl compound, viz. pyroacetyltalatis_x0002_amine and isopryoacetyltalatisamine. The stability of the alkaloid in hot 50 per cent H2S04 is in good agreement with the above structure.

Yunusov, Sichkova, Potemkin.,J. Gen. Chem., USSR, 24, 2237 (1954)
Yunusov, Yunusov., Khim. Prir. Soedin., 4, 198 (1968)