Интерферон гамма

Interferon gamma-lb, a recombinant DNA product, has orphan drug status for the treatment of chronic granulomatous disease. It is also under investigation as a treatment for trauma-related infections and atopic dermatitis.

Antineoplastic; biological response modifier; immunoregulator.

Interferon gamma-1b, Actimmune, is a recombinant proteinexpressed in E. coli. IFN-γ is the cytokine that is secreted byhuman T lymphocytes and NK cells. It is a single-chain glycoproteincomposed of 140 amino acids. The crystal structure of the protein reveals several helical segments arranged toapproximate a toric shape.
Interferon gamma-1b is indicated for reducing the frequencyand severity of serious infections associated withchronic granulomatous disease, an inherited disorder characterizedby deficient phagocyte oxidase activity. In this disease,macrophages try to respond to invading organisms butlack the key oxidative enzymes to dispose of them. To compensate,additional macrophages are recruited into the infectedregion and form a granulomatous structure around thesite. IFN-γ can stimulate the oxidative burst in macrophagesand may reverse the situation.
Interferon gamma-1b is supplied as a solution in sterilewater for injection. The solution must be stored at 2°C to8°C, without freezing. The product cannot tolerate morethan 12 hours at room temperature.