Броксуридин химические свойства, назначение, производство
Химические свойства
White crystalline powder
Использование
A Thymidine analogue used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase
Определение
ChEBI: A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase.
Общее описание
White crystalline powder.
Реакции воздуха и воды
Water soluble.
Профиль реактивности
Broxuridine may be heat and light sensitive. .
Угроза здоровью
ACUTE/CHRONIC HAZARDS: When heated to decomposition Broxuridine emits very toxic fumes of bromide ion and NOx.
Пожароопасность
Flash point data for Broxuridine are not available; however, Broxuridine is probably combustible.
Профиль безопасности
Moderately toxic by
subcutaneous, intravenous, intraperitoneal,
and possibly other routes. Mildly toxic by
ingestion. Experimental teratogenic and
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits very toxic fumes of Brand NOx
Методы очистки
Recrystallise the uridine from EtOH or 96% EtOH. It has max 279 nm at pH 7.0, and 279 nm (log 3.95) at pH 1.9. Its RF values are 0.49, 0.46 and 0.53 in n-BuOH/AcOH/H2O (4:1:1), n-BuOH/EtOH/H2O (40:11:19) and i-PrOH-25% aqueous NH3-H2O (7:1:1), respectively. [Nature 209 230 1966, Pryst.s & Sorm Collect Czech Chem Comm 29 2956 1964, Beilstein 24 III/IV 1234.]
Броксуридин препаратная продукция и сырье
сырьё
препарат