BD 1047 dihydrobromide
|
138356-21-5
|
- CAS №
- 138356-21-5
- английское имя:
- BD 1047 dihydrobromide
- Синонимы:
- 169592;BD1047.2HBr;BD 1047 HBr;BD-1047;BD 1047;BD1047.2HBr(1K/g);BD 1047 (hydrobromide);BD-1047 dihydrobromide, 10 mM in DMSO;BD 1047 dihydrobromide, sigma1 receptor antagonist;N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR;N1-(3,4-dichlorophenethyl)-N1,N2,N2-trimethylethane-1,2-diamine dihydrobromide
- CBNumber:
- CB32755978
- Формула:
- C13H22Br2Cl2N2
- молекулярный вес:
- 437.04118
- MOL File:
- 138356-21-5.mol
|
BD 1047 dihydrobromide атрибут
| температура хранения: |
Inert atmosphere,2-8°C |
| растворимость: |
Н2О: >5мг/мл |
| форма: |
пудра |
| цвет: |
белый |
| Растворимость в воде: |
H2O: >5mg/mL |
| Стабильность:: |
Растворы в ДМСО или дистиллированной воде можно хранить при температуре -20°C до 3 месяцев. |
| UNSPSC Code: |
12352200 |
| NACRES: |
NA.77 |
BD 1047 dihydrobromide химические свойства, назначение, производство
Описание
BD 1047 is a selective antagonist of sigma-1 (σ1) receptors (Ki = 0.9 nM in a radioligand binding assay). It is selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner. In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.
BD 1047 dihydrobromide препаратная продукция и сырье
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BD 1047 dihydrobromide поставщик
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