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PD 166793

структура
199850-67-4
CAS №
199850-67-4
английское имя:
PD 166793
Синонимы:
PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CBNumber:
CB3840520
Формула:
C17H18BrNO4S
молекулярный вес:
412.3
MOL File:
199850-67-4.mol

PD 166793 атрибут

Температура плавления: 192-193℃
плотность: 1.457
температура хранения: Sealed in dry,2-8°C
растворимость: DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
форма: Кристаллическое твердое вещество
цвет: White to pink
FDA UNII: U855L3SOXD

Заявления о рисках и безопасности

PD 166793 химические свойства, назначение, производство

Использование

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

Общее описание

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Биологическая активность

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

PD 166793 препаратная продукция и сырье

сырьё

препарат

PD 166793 поставщик

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199850-67-4()подобный поиск:

ДИФЕНИЛ-2,2-ПИКРИЛГИДРАЗИЛ-1
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