Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate атрибут
| Температура плавления: |
98-100°C |
| Температура кипения: |
456.2±35.0 °C(Predicted) |
| плотность: |
1.131±0.06 g/cm3(Predicted) |
| температура хранения: |
Sealed in dry,2-8°C |
| растворимость: |
хлороформ, этилацетат, метанол |
| форма: |
Твердый |
| пка: |
11.61±0.10(Predicted) |
| цвет: |
Бледно-желтый |
| InChI: |
InChI=1S/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14) |
| ИнЧИКей: |
KZBJJAFGNMRRHN-UHFFFAOYSA-N |
| SMILES: |
C1(CCC)NC(C(OCC)=O)=C(C(O)(C)C)N=1 |
| Справочник по базе данных CAS: |
144689-93-0(CAS DataBase Reference) |
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate химические свойства, назначение, производство
Химические свойства
Pale Yellow Solid
прикладной
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a synthetic drug with pharmacological properties that are similar to those of the natural product medoxomil. It has been shown to be a potent blocker of the GABA receptor and is used for the treatment of epilepsy.It has been shown to be an inhibitor of rat liver microsomes and also has a high affinity for the enzyme cilexetil, which is responsible for the conversion of cilexetil into its active form.
Определение
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a crucial intermediate for the synthesis of olmesartan medoxomil, which can be produced via the reaction of diethyl 2-propyl-imidazole-4,5-dicarboxylate, the raw material, with methylmagnesium bromide, followed by the acidification with saturated ammonium chloride solution.
Опасность
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is sensitive to the skin and may cause allergic skin reactions. It is irritating to the skin and eyes and may also cause respiratory irritation. It is poisonous to aquatic organisms.
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate препаратная продукция и сырье
сырьё
препарат
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate поставщик
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