PD-166866
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192705-79-6
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- CAS №
- 192705-79-6
- Химическое название:
- PD-166866
- английское имя:
- PD 166866
- Синонимы:
- CS-2496;PD 166866;PD-166866;PD 166866;FGF Receptor Tyrosine Kinase Inhibitor;FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem;tert-butyl (2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)carbamate;1-(2-aMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)-3-(tert-butyl)urea;N-[2-AMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl);Inhibitor,Autophagy,FGFR,inhibit,PD-166866,PD 166866,Fibroblast growth factor receptor;Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
- CBNumber:
- CB42485694
- Формула:
- C20H24N6O3
- молекулярный вес:
- 396.44
- MOL File:
- 192705-79-6.mol
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PD-166866 атрибут
| Температура плавления: |
291-293°C |
| температура хранения: |
2-8°C |
| растворимость: |
ДМСО: ≥10 мг/мл |
| форма: |
Белое твердое вещество |
| цвет: |
от белого до светло-коричневого |
| FDA UNII: |
NA856793UT |
PD-166866 химические свойства, назначение, производство
Описание
PD 166866 is a potent inhibitor of fibroblast growth factor receptor 1 (FGFR1; IC50 = 52.4 nM; Ki = 45.2 nM). It is selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM). PD 166866 inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively) and inhibits phosphorylation of MAPK (IC50s = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively). It reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro. PD 166866 inhibits the growth of non-small cell lung cancer (NSCLC) cell lines in a dose-dependent manner and reduces migration of VL-8 cells at a concentration of 10 μM.
Химические свойства
Off-White Solid
Использование
A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF).
PD-166866 препаратная продукция и сырье
сырьё
препарат
PD-166866 поставщик
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