AZD7545
252017-04-2
|
- CAS №
- 252017-04-2
- английское имя:
- AZD7545
- Синонимы:
- AZD7545;AZD4575;CS-1842;AZD-7547;AZD 7547;AZD7547;AZD7545/AZD-7545;PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545;(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
- CBNumber:
- CB42627360
- Формула:
- C19H18ClF3N2O5S
- молекулярный вес:
- 478.87
- MOL File:
- 252017-04-2.mol
|
AZD7545 атрибут
Температура кипения: |
683.1±55.0 °C(Predicted) |
плотность: |
1.473±0.06 g/cm3(Predicted) |
температура хранения: |
2-8°C |
растворимость: |
≥21,85 мг/мл в ДМСО; нерастворим в H2O; ≥15,63 мг/мл в EtOH с помощью ультразвука |
форма: |
Твердый |
пка: |
10.39±0.29(Predicted) |
цвет: |
White to off-white |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
AZD7545 химические свойства, назначение, производство
Описание
AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC50 value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC50s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC50 = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.
AZD7545 препаратная продукция и сырье
сырьё
препарат
AZD7545 поставщик
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