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Dolutegravir Impurity 6

 структура
1357289-29-2
CAS №
1357289-29-2
английское имя:
Dolutegravir Impurity 6
Синонимы:
Dotiravir Impurity 12;Dolutegravir RR Isomer;Dolutegravir Impurity 6;Doultegravirr RR Isomer;Dolutegravir Impurity 42;Dolutegravir R,R Freebase / R,R-ISomer;4-(3-chlorothiophen-2-yl)-1,3-thiazol-2-amine;(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-(2,5-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4, 6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine9-carboxamide;(4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12, 12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H- pPyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CBNumber:
CB43154308
Формула:
C20H19F2N3O5
молекулярный вес:
419.38
MOL File:
1357289-29-2.mol

Dolutegravir Impurity 6 атрибут

Температура кипения: 669.0±55.0 °C(Predicted)
плотность: 1.53±0.1 g/cm3(Predicted)
пка: 4.50±1.00(Predicted)
FDA UNII: KA8ZEA9QPD

Заявления о рисках и безопасности

Dolutegravir Impurity 6 химические свойства, назначение, производство

Использование

Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 6 препаратная продукция и сырье

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