ИНГЕНОЛ
ИНГЕНОЛ атрибут
| Температура плавления: |
153 °C |
| Температура кипения: |
523.8±50.0 °C(Predicted) |
| плотность: |
1.33±0.1 g/cm3(Predicted) |
| температура хранения: |
Sealed in dry,Store in freezer, under -20°C |
| растворимость: |
ДМСО: растворимый |
| форма: |
фильм |
| пка: |
12.06±0.70(Predicted) |
| цвет: |
Бесцветный и прозрачный |
| FDA UNII: |
IC77UZI9G8 |
ИНГЕНОЛ химические свойства, назначение, производство
Описание
Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
Использование
Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.
Определение
ChEBI: A tetracyclic diterpenoid that is 1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one substituted at positions 5, 5a and 6 by hydroxy groups, positions 1, 1, 7 and 9 by met
yl groups, position 4 by a hydroxymethyl group and position 1 by an oxo group (the 1aR,2S,5R,5aR,6S,8aS,9R,10aR diastere
mer).
ИНГЕНОЛ препаратная продукция и сырье
сырьё
1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 4-[(acetyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
20-ДЕОКСИНГЕНОЛ
Ингенол мебутат
препарат
(1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
ИНГЕНОЛ поставщик
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