Цефпрозил химические свойства, назначение, производство
Описание
Cefprozil is a new orally active cephalosporin useful in the treatment of otitis media,
uncomplicated skin and skin structure infections plus upper/lower respiratory tract
infections. Although structurally similar to cefadroxil, its spectrum of antibacterial
activity is comparable to cefaclor, but exhibits greater activity against S.aureus, S.
epidermidis, Listeria monocytogenes, Streptococci, H. influenzae, Propionibacterium
acnes. Clostridium perfringens and difficile.
Химические свойства
Pale Yellow Solid
Использование
Semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial
Определение
ChEBI: A semisynthetic, second-generation cephalosporin, with prop-1-enyl and (R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used to treat bronchitis as well as ear, skin and other bacterial infec
ions.
Антимикробная активность
Activity against Gram-positive cocci and Gram-negative
bacilli is better than that of cefadroxil (which it structurally
resembles) but is not as good as that of group 5 agents
. It is moderately stable to hydrolysis
by the common plasmid-mediated β-lactamases, but is hydrolyzed
by the chromosomal enzymes of Gram-negative bacilli
.
Опасность
Moderately toxic by ingestion. Human sys-
temic effects.
Клиническое использование
Cefprozil (Cefzil) is an orally active second-generationcephalosporin that is similar in structure and antibacterialspectrum to cefadroxil. Oral absorption is excellent (oralbioavailability is about 95%) and is not affected by antacidsor histamine H2-antagonists. Cefprozil exhibits greater invitro activity against streptococci, Neisseria spp., and S. aureusthan does cefadroxil. It is also more active than thefirst-generation cephalosporins against members of theEnterobacteriaceae family, such as E. coli, Klebsiella spp., P. mirabilis, and Citrobacter spp. The plasma half-life of1.2 to 1.4 hours permits twice-a-day dosing for the treatmentof most community-acquired respiratory and urinary tractinfections caused by susceptible organisms.
Побочные эффекты
It is well tolerated. Diarrhea and gastrointestinal discomfort
may occur. There have been a few reports of pseudomembranous
colitis and serum sickness-like reactions.
Цефпрозил препаратная продукция и сырье
сырьё
препарат