6-chloro-2-methyl-2H-indazol-5-amine
6-chloro-2-methyl-2H-indazol-5-amine атрибут
| Температура кипения: |
365.6±22.0 °C(Predicted) |
| плотность: |
1.45±0.1 g/cm3(Predicted) |
| пка: |
2.05±0.10(Predicted) |
| InChI: |
InChI=1S/C8H8ClN3/c1-12-4-5-2-7(10)6(9)3-8(5)11-12/h2-4H,10H2,1H3 |
| ИнЧИКей: |
YRZNRFJEBAPCCO-UHFFFAOYSA-N |
| SMILES: |
N1=C2C(C=C(N)C(Cl)=C2)=CN1C |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
6-chloro-2-methyl-2H-indazol-5-amine химические свойства, назначение, производство
Синтез
A suspension of 6-Chloro-1-methyl-5-nitro-1H-indazole (700 mg, 3.31 mmol), NH4CI (1 .59g, 29.77mmol) & Fe powder (1.66g, 29.77mmol) in a mixture of EtOH: Water (15mL: 15mL) was heated to 80°C for 6h. After 6h, TLC analysis indicated the formation of a polar spot (Ninhydrin positive). Then, the reaction mixture was cooled to RT and filtered through the celite bed; the celite bed was washed with EtOH (50mL); the filtrate was concentrated under reduced pressure to give a crude product. The crude product was purified by column chromatography (silica gel 100-200mesh) using 25% EtOAc in petroleum ether as an eluent to give 6- chloro-2-methyl-2H-indazol-5-amine (quantitative yield) as an off-white solid.
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6-chloro-2-methyl-2H-indazol-5-amine поставщик
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