O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI атрибут
| Температура плавления: |
172-175°C |
| плотность: |
1.53 |
| температура хранения: |
-20°C |
| растворимость: |
Растворим в ДМСО (до 35 мг/мл) |
| форма: |
Твердый |
| пка: |
11.85±0.70(Predicted) |
| цвет: |
белый |
| БРН: |
4274031 |
| Стабильность:: |
Чувствителен к влаге и температуре |
| FDA UNII: |
AWZ7VE64B6 |
| UNSPSC Code: |
12352204 |
| NACRES: |
NA.26 |
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI химические свойства, назначение, производство
Описание
Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.
Химические свойства
White to Off-White Solid
Использование
An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B
Биологическая активность
O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI препаратная продукция и сырье
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O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI поставщик
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