4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
39674-97-0
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- CAS №
- 39674-97-0
- английское имя:
- 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
- Синонимы:
- BVT 948;BVT-948
(SPS8I-3);4-HYDROXY-3,3-DIMETHYL-2H-BENZ[G]INDOLE-2,5(3H)-DIONE;4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE;2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl-;Cytochrome P450,Histone Methyltransferase,BVT 948,BVT948,Inhibitor,Phosphatase,CYPs,BVT-948,inhibit
- CBNumber:
- CB5736256
- Формула:
- C14H11NO3
- молекулярный вес:
- 241.24
- MOL File:
- 39674-97-0.mol
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4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE атрибут
Температура кипения: |
400.8±55.0 °C(Predicted) |
плотность: |
1.39±0.1 g/cm3(Predicted) |
температура хранения: |
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
растворимость: |
ДМСО: 18 мг/мл |
форма: |
Твердый |
пка: |
5.78±0.40(Predicted) |
цвет: |
Красный |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
Коды опасности |
Xi |
Заявления о рисках |
43 |
Заявления о безопасности |
36/37 |
WGK Германия |
3 |
символ(GHS) |
|
сигнальное слово |
Warning |
Заявление об опасности |
пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
H317 |
При контакте с кожей может вызывать аллергическую
реакцию. |
Сенсибилизация, Кожа |
Категория 1 |
Предупреждение |
![](/GHS07.jpg) |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
|
Внимание |
P280 |
Использовать перчатки/ средства защиты глаз/ лица. |
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4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE химические свойства, назначение, производство
Описание
BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC50s = 0.09-1.7 μM). It facilitates the oxidation of the catalytic cysteine residue by hydrogen peroxide. Similarly, it inhibits redox-sensitive cytochrome P450 (CYP) isoforms, including CYP2C19 and CYP2D6, with IC50 values less than 10 μM. BVT 948 also inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3 with IC50 values from 0.7 to 3.2 μm. Presumably through its effects on PTPs, BVT 948 enhances insulin signaling in cells and insulin tolerance in ob/ob mice, suppresses the expression of matrix metalloproteinase-9 and invasion in breast cancer cells, and increases NMDA-induced substance P release by spinal cord slices.
Использование
BVT-948 is a noncompetitive cell-permeable inhibitor of tyrosine phosphatases. Helps in the oxidation of the catalytic cysteine residue. May be used as an anti-cancer treatment.
Биологическая активность
Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC 50 = 0.09-1.7 μ M); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo . Also inhibits several cytochrome P450 isoforms (IC 50 < 10 μ M).
4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE препаратная продукция и сырье
сырьё
препарат
4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE поставщик
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