Mexiletine hydrochloride
Mexiletine hydrochloride атрибут
| Температура плавления: |
200-203°C |
| плотность: |
1.12 g/cm3 |
| температура хранения: |
2-8°C |
| растворимость: |
этанол: 50 мг/мл |
| форма: |
пудра |
| пка: |
9.0(at 25℃) |
| цвет: |
белый |
| λмакс: |
272nm(MeOH)(lit.) |
| Мерк: |
14,6169 |
| Стабильность:: |
гигроскопичный |
| Справочник по базе данных CAS: |
5370-01-4(CAS DataBase Reference) |
| FDA UNII: |
606D60IS38 |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
| Коды опасности |
Xn |
| Заявления о рисках |
20/21/22-36/37/38-22 |
| Заявления о безопасности |
36-26 |
| WGK Германия |
3 |
| RTECS |
KR9300000 |
| кода HS |
2922190900 |
| Токсичность |
LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast) |
| символ（GHS） |
|
| сигнальное слово |
Warning |
| Заявление об опасности |
| пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
| H302 |
Вредно при проглатывании. |
Острая токсичность, пероральная |
Категория 4 |
Предупреждение |
|
P264, P270, P301+P312, P330, P501 |
|
| Внимание |
| P301+P312+P330 |
ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью
при плохом самочувствии. Прополоскать рот. |
|
Mexiletine hydrochloride химические свойства, назначение, производство
Описание
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.
Химические свойства
White to Off-White Solid
Использование
Mexiletine hydrochloride has been used as a sodium channel blocker:
- expressed in chinese hamster ovary cells
- in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
- electrophysiology studies in HEK cells expressing Nav1.7 protein
Определение
ChEBI: A hydrochloride composed of equimolar amounts of mexiletine and hydrogen chloride.
Общее описание
Mexiletine hydrochloride,1-methyl-2-(2,6-xylyloxy)ethylamine hydrochloride (Mexitil)(pKa 8.4), is a class IB antiarrhythmic agent that is effectivewhen given either intravenously or orally. It resembles lidocainein possessing a xylyl moiety but otherwise is differentchemically. Mexiletine hydrochloride is an ether and is notsubject to the hydrolysis common to the amides lidocaineand tocainide. Its mean half-life on oral administration isapproximately 10 hours.
Although not subject to hydrolysis, mexiletine hydrochlorideis metabolized by oxidative and reductiveprocesses in the liver. Its metabolites, p-hydroxymexiletineand hydroxymethylmexiletine, are not pharmacologicallyactive as antiarrhythmic agents.
Биологическая активность
Use-dependent sodium channel blocker (IC 50 values are 75.3 and 23.6 μ M for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
Клиническое использование
Mexiletine hydrochloride, like class I antiarrhythmicagents, blocks the fast Na channel in cardiac cells. It isespecially effective on the Purkinje fibers in the heart. Thedrug increases the threshold of excitability of myocardialcells by reducing the rate of rise and amplitude of the actionpotential and decreases automaticity.
Mexiletine hydrochloride is used for long-term oral prophylaxisof ventricular tachycardia. The drug is given in200- to 400-mg doses every 8 hours.
Mexiletine hydrochloride препаратная продукция и сырье
сырьё
препарат
Mexiletine hydrochloride поставщик
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