NF 279

202983-32-2

CAS №: 202983-32-2

английское имя:: NF 279

Синонимы:: NF 279;CS-319;NF279 - CAS 202983-32-2 - Calbiochem;8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid;8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt;8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt

CBNumber:: CB6135641

Формула:: C49H37N6NaO23S6

молекулярный вес:: 1293.2

MOL File:: 202983-32-2.mol

атрибут

безопасность

использование

поставщик 47

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NF 279 атрибут

температура хранения:	Desiccate at -20°C
растворимость:	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
форма:	Белое твердое вещество
цвет:	White to off-white
Растворимость в воде:	Растворим до 25 мМ в воде
Стабильность::	Hygroscopic

Заявления о рисках и безопасности

NF 279 химические свойства, назначение, производство

Использование

NF 279 is a potent and selective P2X1 antagonist.

Общее описание

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/K_B ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α_1A adrenoceptors, adenosine A₁ and A_2B receptors, histamine H₁, muscarinic M₃ and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X₁ >P2X₂ >P2X₃ >P2X₄ (IC₅₀ = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X₁ > human P2X₁ ? rat P2X₂ > rat P2X₃ ~human P2X₇ ? human P2X₄. Not degraded by ecto-nucleotidases.

Биологическая активность

A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

NF 279 препаратная продукция и сырье

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NF 279 поставщик

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