ХОЛИН хлористый химические свойства, назначение, производство
Химические свойства
White crystalline powder
прикладной
Choline chloride has been used:
as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices
Определение
ChEBI: Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.
преимущество
choleretic, lipotropic, hepatoprotectant
Общее описание
Choline chloride appears as white crystals. Practically neutral aqueous solution(NTP, 1992). It is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Реакции воздуха и воды
Deliquescent. Very soluble in water.
Профиль реактивности
An acidic organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Пожароопасность
Choline chloride is relatively nonflammable.
Профиль безопасности
Poison by
intraperitoneal and intravenous routes.
Moderately toxic experimentally by ingestion
and subcutaneous routes. Mutation data
reported. A lipotropic agent which induces
the reduction in fats contained in the liver.
When heated to decomposition it emits
toxic fumes of Cl-, SOx and NOx. See also
CHOLINE.
Методы очистки
Extremely deliquescent. Check purity by AgNO3 titration or by titration of OH-base after passage through an anion-exchange column. Crystallise it from absolute EtOH, or EtOH/Et2O, dry it under vacuum and store it in a vacuum desiccator over P2O5 or Mg(ClO4)2. [Beilstein 4 IV 1443.]
ХОЛИН хлористый препаратная продукция и сырье
сырьё
препарат