Usnic acid
Usnic acid атрибут
| Температура плавления: |
200°C |
| альфа: |
D16 +509.4° (c = 0.697 in chloroform) |
| Температура кипения: |
399.43°C (rough estimate) |
| плотность: |
1.2869 (rough estimate) |
| показатель преломления: |
495 ° (C=0.7, CHCl3) |
| температура хранения: |
under inert gas (nitrogen or Argon) at 2-8°C |
| растворимость: |
DMF:2.5(Max Conc. mg/mL);7.26(Max Conc. mM) |
| форма: |
Кристаллическое твердое вещество |
| пка: |
4.00±0.40(Predicted) |
| цвет: |
White to yellow |
| Мерк: |
9893 |
| LogP: |
2.880 |
| Справочник по базе данных CAS: |
125-46-2(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
0W584PFJ77 |
| Система регистрации веществ EPA: |
Usnic acid (125-46-2) |
Usnic acid химические свойства, назначение, производство
Химические свойства
Crystalline, yellow solid. Insoluble in water; slightly soluble in
alcohol and ether.
Использование
Usnic acid is a major metabolite from a number of lichen and fungal species and is perhaps one of the longest known microbial metabolites, first isolated in 1844. Usnic acid exhibits a broad range of biological activity, indeed it is easier to list the bioassays in which it does not exhibit activity. More often than not, potency is low and of limited value. Usnic acid is an important metabolite for dereplication in discovery research programs.
Определение
ChEBI: A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.
Контактные аллергены
Usnic acid is a component of lichens, also used as a
topical antibiotic. Allergic contact dermatitis from
lichens occurs mainly occupationally in forestry and
horticultural workers, and in lichen pickers.
Методы очистки
This very weak acid is the natural form which is recrystallised from Me2CO, MeOH or *C6H6. At 25o it is soluble in H2O (<0.01%), Me2CO (0.77%), EtOAc (0.88%), MeOCH2CH2OH (0.22%) and furfural (7.32%). [Curd & Robertson J Chem Soc 894 1937, Barton & Brunn J Chem Soc 603 1953, resolution: Dean et al. J Chem Soc 1250 1953, synthesis: Barton et al. J Chem Soc 538 1956, Beilstein 18/5 V 586.]
Usnic acid препаратная продукция и сырье
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Usnic acid поставщик
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125-46-2(Usnic acid)подобный поиск: