7-Ethyl-10-hydroxycamptothecin

130144-34-2

CAS №: 130144-34-2

английское имя:: 7-Ethyl-10-hydroxycamptothecin

Синонимы:: Camptothecin Impurity 21;7-Ethyl-10-hydroxycamptothecin;(rac)-7-Ethyl-10-Hydroxy camptothecin;rac-4,11-Diethyl-9-hydroxycamptothecin;7-Ethyl-10-hydroxycamptothecin, racemic;(110714-48-2) 7-ethyl-10-hydroxycamptothecin;1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CBNumber:: CB62462141

Формула:: C22H20N2O5

молекулярный вес:: 392.41

MOL File:: 130144-34-2.mol

атрибут

безопасность

использование

поставщик 67

продукт поиска:

7-Ethyl-10-hydroxycamptothecin атрибут

Температура кипения:	810.3±65.0 °C(Predicted)
плотность:	1.51
пка:	9.13±0.40(Predicted)
InChI:	InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3
ИнЧИКей:	FJHBVJOVLFPMQE-UHFFFAOYSA-N
SMILES:	N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O

Заявления о рисках и безопасности

7-Ethyl-10-hydroxycamptothecin химические свойства, назначение, производство

Описание

7-Ethyl-10-hydroxycamptothecin: a potent topoisomerase I inhibitor
7-Ethyl-10-hydroxycamptothecin (SN-38), as a highly active topoisomerase (Topo) I inhibitor, is the active metabolic product of its prodrug irinotecan (CPT-11) commercially available as Camptosar. By combining with the Topo I-DNA covalent conjugate, the camptothecin analogue forms a ternary complex that blocks the repolymerization of the DNA strands during their replication, eventually leading to the cell apoptosis. Although SN-38 is about 100- to 1000-fold more potent than irinotecan, its clinical application is limited by its poor solubility and nonspecific toxicity[1].

7-Ethyl-10-hydroxycamptothecin препаратная продукция и сырье

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препарат

7-Ethyl-10-hydroxycamptothecin поставщик

Global( 67)Suppliers

поставщик	телефон	страна	номенклатура продукции	благоприятные условия
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.	+86-028-60118998 +8615830127659	China	24	58
Xiamen Eagle Chemical Limited Corporation		China	5699	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	China	25356	58
career henan chemical co	+86-0371-86658258 +8613203830695	China	29809	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58
Nantong Runfeng Petrochemical Co., Ltd	18912298907 18912298907	China	4908	58
JIANGSU BSECHEM CHEMICAL TECHNOLOGY Co., Ltd	15651337098	China	4468	58
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd	18117346937 18117346937	China	4743	58
Shandong WorldSun Biological Technology Co., Ltd.	0531-88723173 18596073690	China	5018	58
Jiangsu Pules Bio-tech Co.,Ltd	0513-66017706 18551496367	China	4711	58