6-Maleimidocaproic acid
6-Maleimidocaproic acid атрибут
| Температура плавления: |
86-91 °C |
| Температура кипения: |
407.3±28.0 °C(Predicted) |
| плотность: |
1.285±0.06 g/cm3(Predicted) |
| температура хранения: |
2-8°C |
| растворимость: |
ДМСО (немного), этилацетат (немного) |
| форма: |
пудра |
| пка: |
4.74±0.10(Predicted) |
| цвет: |
От белого до бледно-желтого |
| Растворимость в воде: |
Растворим в воде, метаноле, этаноле, диметилсульфоксиде. Нерастворим в эфире. |
| Чувствительный: |
Moisture Sensitive |
| БРН: |
1532405 |
| InChI: |
InChI=1S/C10H13NO4/c12-8-5-6-9(13)11(8)7-3-1-2-4-10(14)15/h5-6H,1-4,7H2,(H,14,15) |
| ИнЧИКей: |
WOJKKJKETHYEAC-UHFFFAOYSA-N |
| SMILES: |
N1(CCCCCC(O)=O)C(=O)C=CC1=O |
| Справочник по базе данных CAS: |
55750-53-3(CAS DataBase Reference) |
| Система регистрации веществ EPA: |
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- (55750-53-3) |
| UNSPSC Code: |
12352005 |
| NACRES: |
NA.25 |
6-Maleimidocaproic acid химические свойства, назначение, производство
Химические свойства
White to yellow solid, powder, crystals or crystaline powder.
Определение
ChEBI: 6-Maleimidocaproic acid is a medium-chain fatty acid. It contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
прикладной
6-Maleimidocaproic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent. It can be widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. Spacer Arm: 9.4 Angstroms. Probe for thiol groups (SH-groups) in membrane proteins.
Синтез
Maleic anhydride (29.4 g, 0.3 mol) and 6-aminocaproic acid (39.35 g, 0.3 mol) were refluxed in
glacial acetic acid (900 mL) for 16 h. Acetic anhydride (30.6 g, 0.3 mol) was added dropwise over
a period of 2 hand reflux was continued for 1 h. The acetic acid was removed under vacuum at 70
°C to yield yellow syrup which solidified. The material was chromatographed over silica using
dichloromethane-methanol-acetic acid (100:5:1) affording a crystalline solid (6-Maleimidocaproic acid).
6-Maleimidocaproic acid препаратная продукция и сырье
сырьё
препарат
MC-Val-Cit-PAB
Mc-Val-Cit-PABC-PNP
McMMAE
Карбаминовая кислота, [5-(2,5-дигидро-2,5-диоксо-1H-пиррол-1-ил)пентил]-,1,1-диметилэтиловый эфир
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[(1,1-diMethylethoxy)carbonyl]hydrazide
6-Maleimidocaproic acid поставщик
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