OLEIC-1-13C ACID 99 ATOM % 13C
OLEIC-1-13C ACID 99 ATOM % 13C атрибут
| Температура плавления: |
13.4 °C(lit.) |
| Температура кипения: |
192-195 °C1.2 mm Hg(lit.) |
| плотность: |
0.893 g/mL at 25 °C |
| показатель преломления: |
n20/D 1.4595(lit.) |
| Fp: |
>230 °F(lit.) |
| температура хранения: |
-20°C |
| растворимость: |
Ethanol: 1.5 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| форма: |
Liquid |
| цвет: |
Colorless to light yellow |
OLEIC-1-13C ACID 99 ATOM % 13C химические свойства, назначение, производство
Описание
Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid (Item Nos. 90260 | 24659) by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 μg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 μM, similar to arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607). Oleic acid (60 μM) induces release of intracellular calcium in human platelets. In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).
Использование
Labelled Oleic acid. Obtained by the hydrolysis of various animal and vegetable fats and oils.
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