1-AZAKENPAULLONE химические свойства, назначение, производство
Химические свойства
Tan Solid
Использование
A selective inhibitor of glycogen synthase kinase-3β.
Общее описание
A Kenpaullone (
>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC
50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC
50 = 2.0 μM and 4.2 μM, respectively). The solid form of this compound (Cat. No.
191500) is also available.
Ферментативный ингибитор
This cell-permeable protein kinase inhibitor (FW = 328.17 g/mol; CAS 676596-65-9: Solubility: 66 mg/mL DMSO; <1 mg/mL H2O), also named 9-bromo-7,12-dihydro-pyrido[3,2’:2,3]azepino[4,5-b]indol-6(5H)-one, selectively and potently targets glycogen synthase kinase 3β, or GSK3β (IC50 = 18 nM) with 100x less inhibitory action against cyclin-dependent kinases (CDKs). 1-Azakenpaullone has become a gold standard for GSK3 inhibition.
1-AZAKENPAULLONE препаратная продукция и сырье
сырьё
препарат