N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]OCTADECANAMIDE

STEARDA is a novel, endogenous capsaicin-like lipid that produces hyperalgesia.

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB 1 receptors (at concentrations up to 5 μ M) and does not inhibit AMT or FAAH (IC 50 > 25 μ M). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo ; enhances effects on intracellular Ca 2+ (EC 50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC 50 = 16 nM).