42-(Dimethylphosphinate)rapamycin
42-(Dimethylphosphinate)rapamycin атрибут
| Температура плавления: |
95-98°C |
| Температура кипения: |
996.2±75.0 °C(Predicted) |
| плотность: |
1.18±0.1 g/cm3(Predicted) |
| температура хранения: |
Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| растворимость: |
ДМСО (Мало растворим), метанол (Мало растворим) |
| пка: |
10.40±0.70(Predicted) |
| форма: |
Твердый |
| цвет: |
От белого до бледно-желтого |
| Стабильность:: |
гигроскопичный |
| FDA UNII: |
48Z35KB15K |
| Словарь онкологических терминов NCI: |
ridaforolimus |
| Словарь наркотиков NCI: |
ridaforolimus |
| Код УВД: |
L01EG03 |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
42-(Dimethylphosphinate)rapamycin химические свойства, назначение, производство
Описание
MK-8669 is a rapamycin analog that selectively inhibits mTOR (IC50 = 0.2 nM). Like rapamycin, MK-8669 binds FKBP12 to form a complex that associates with the FKBP-rapamycin binding domain on mTOR and allosterically inhibits mTORC1 kinase activity. MK-8669 is more water soluble than rapamycin and is amenable to oral or intravenous administration. Formulations containing rapalogs, including MK-8669, have promise against a subset of cancers, including advanced kidney cancer. MK-8669 is also being examined for effectiveness against cancers when used in combination with other chemotherapeutic compounds.
Химические свойства
Off-White Solid
Определение
ChEBI: A semisynthetic derivative that is sirolimus in which hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.
42-(Dimethylphosphinate)rapamycin препаратная продукция и сырье
сырьё
препарат
42-(Dimethylphosphinate)rapamycin поставщик
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