CHLORISONDAMINE DIIODIDE
CHLORISONDAMINE DIIODIDE атрибут
| температура хранения: |
2-8°C |
| растворимость: |
H2O: ~3,75 мг/мл |
| форма: |
Твердый |
| цвет: |
белый |
| Растворимость в воде: |
Растворим до 10 мМ в воде |
| UNSPSC Code: |
12352116 |
| NACRES: |
NA.77 |
CHLORISONDAMINE DIIODIDE химические свойства, назначение, производство
Описание
Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
Использование
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Биохимия/физиол Действия
Chlorisondamine diiodide mediates ganglionic and central blockade.
CHLORISONDAMINE DIIODIDE препаратная продукция и сырье
сырьё
препарат
CHLORISONDAMINE DIIODIDE поставщик
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