L-A-HYDROXYGLUTARIC ACID DISODIUM)
L-A-HYDROXYGLUTARIC ACID DISODIUM) атрибут
| Температура плавления: |
>300°C |
| температура хранения: |
2-8°C |
| растворимость: |
Methanol (Very Slightly), Water (Slightly) |
| форма: |
Твердый |
| цвет: |
От белого до не совсем белого |
| оптическая активность: |
[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH |
| БРН: |
5318042 |
Заявления о рисках и безопасности
L-A-HYDROXYGLUTARIC ACID DISODIUM) химические свойства, назначение, производство
Описание
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.
Химические свойства
White Solid
Использование
A potential inhibitor of glutamate carboxypeptidase.
Общее описание
Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.
L-A-HYDROXYGLUTARIC ACID DISODIUM) препаратная продукция и сырье
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L-A-HYDROXYGLUTARIC ACID DISODIUM) поставщик
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