Atogepant (MK-8031)

1374248-81-3

CAS №: 1374248-81-3

английское имя:: Atogepant (MK-8031)

Синонимы:: MK-8031;AGN-241689）;Atogepant API;MK8031. Atogepant;Atogepant Monohydrate;(3'S)-1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-Spiro[6H-;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamid;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxamide;(S)-N-((3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide;(3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide

CBNumber:: CB83368673

Формула:: C29H23F6N5O3

молекулярный вес:: 603.52

MOL File:: 1374248-81-3.mol

атрибут

безопасность

использование

поставщик 52

продукт поиска:

Atogepant (MK-8031) атрибут

Температура кипения:	693.9±55.0 °C(Predicted)
плотность:	1.54±0.1 g/cm3(Predicted)
температура хранения:	Store at -20°C
пка:	11.08±0.20(Predicted)
форма:	Solid
цвет:	White to off-white
ИнЧИКей:	QIVUCLWGARAQIO-OLIXTKCUSA-N
SMILES:	C12C[C@@]3(C(=O)NC4=NC=CC=C43)CC1=CC(C(N[C@H]1C[C@@H](C3=C(F)C=CC(F)=C3F)[C@@H](C)N(CC(F)(F)F)C1=O)=O)=CN=2
FDA UNII:	7CRV8RR151

Заявления о рисках и безопасности

Atogepant (MK-8031) химические свойства, назначение, производство

Использование

Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

Побочные эффекты

The side effect profile of atogepant is similar to other gepants, most frequently including constipation, nausea, upper respiratory and urinary tract infection, and appearing similarly in long-term follow-up studies and clinical trials. Currently, there is no data on the safety of atogepant treatment during pregnancy or lactation. However, it can be assumed, based on animal data, that it is able to pass into breast milk.

Atogepant (MK-8031) препаратная продукция и сырье

сырьё

препарат

Atogepant (MK-8031) поставщик

Global( 52)Suppliers

поставщик	телефон	страна	номенклатура продукции	благоприятные условия
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	China	5221	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	China	294	58
LEAPCHEM CO., LTD.	+86-852-30606658	China	43340	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10986	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	China	9258	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	China	23046	58
TargetMol Chemicals Inc.		United States	38466	58
SyncoZymes (Shanghai) Co., Ltd.,	+86-021-68187180-811 +86-13681683526	China	188	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10473	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32072	58