ИНГИБИТОР ФУРИНОВ II
ИНГИБИТОР ФУРИНОВ II атрибут
| плотность: |
1.59±0.1 g/cm3(Predicted) |
| температура хранения: |
Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| растворимость: |
H2O: 50 мг/мл (52,40 мМ; требуется ультразвук) ДМСО: 5 мг/мл (5,24 мМ; требуется ультразвук) |
| пка: |
13.24±0.46(Predicted) |
| форма: |
лиофилизированный |
| цвет: |
White to off-white |
| Растворимость в воде: |
Soluble to 2 mg/ml in water |
ИНГИБИТОР ФУРИНОВ II химические свойства, назначение, производство
Использование
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
Общее описание
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.
Биохимия/физиол Действия
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein?4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases?and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).
ИНГИБИТОР ФУРИНОВ II препаратная продукция и сырье
сырьё
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ИНГИБИТОР ФУРИНОВ II поставщик
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