4 - [(5,6,7,8-ТЕТРАГИДРО-5,5,8,8-ТЕТРАМЕТИЛ-2-НАФТАЛИНИЛ) КАРБОКСАМИДО] БЕНЗОЙНАЯ КИСЛОТА химические свойства, назначение, производство
Использование
Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.
Определение
ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Общее описание
AM580 is a retinobenzoic derivative and a RAR-α (retinoic acid receptor-α) agonist. It stimulates the maturation of granulocytes in NB4 promyelocytic leukemia cell line and APL (acute promyelocytic leukemia) blasts. AM580 suppresses endometrial cancer cell proliferation.
Биологическая активность
An analog of retinoic acid that acts as a selective RAR α agonist (EC 50 values are 0.3, 8.6 and 13 nM for RAR α , RAR β and RAR γ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFN γ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro .
4 - [(5,6,7,8-ТЕТРАГИДРО-5,5,8,8-ТЕТРАМЕТИЛ-2-НАФТАЛИНИЛ) КАРБОКСАМИДО] БЕНЗОЙНАЯ КИСЛОТА препаратная продукция и сырье
сырьё
препарат