Effect of dietary proline and hydroxyproline on tensile strength of healing wounds.

Abstract

Summary Protein depleted rats were given dietary supplements of .5% synthetic d-l hydroxyproline and 1% synthetic d-l proline. Guinea pigs on an ascorbic acid deficient diet were given a dietary supplement of .5% d-l hydroxyproline. The animals were wounded by a standard technic and the tensile strength of their healing wounds was tested at 48-hour intervals between the 6th and 21st postoperative days. Neither hydroxyproline nor proline exerted a significant effect upon the rate of gain of tensile strength in the wounds of protein deficient rats or scorbutic guinea pigs.