CHLORFENAC
Product identifier
- Product name: CHLORFENAC
- CBnumber: CB9445521
- CAS: 85-34-7
- EINECS Number: 201-599-3
- Synonyms: chlorfenac,2,3,6-Trichlorobenzeneacetic acid
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Label elements
Pictogram(s)
- Signal wordWarning
H302 Harmful if swallowed
H411 Toxic to aquatic life with long lasting effects
P273 Avoid release to the environment.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: CHLORFENAC
- Synonyms: chlorfenac,2,3,6-Trichlorobenzeneacetic acid
- CAS: 85-34-7
- EC number: 201-599-3
- MF: C8H5Cl3O2
- MW: 239.48
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and Excretion52.8% of a dose was excreted in the urine of a lactating cow as 2,3,6-trichlorophenylacetic acid ester glucuronide & 18.6% as the free acid. fenac components were not excreted by either the fecal or mammary routes. fenac was unmetabolized by liver drug-metabolizing enzymes & ruminal microflora.
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical stateneat
- ColourColorless crystals
- Odour
no data available
- Melting point/freezing point
161°C
- Boiling point or initial boiling point and boiling range
353.5°C at 760 mmHg
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
167.6°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
SOL IN ACETONE, ALC, ETHER
- Partition coefficient n-octanol/water
3.2
- Vapour pressure
1.7x10-5 mm Hg at 25 deg C
- Density and/or relative density
1.568
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
No shelf life limitations. Not harmed by freeze thaw cycles.
Possibility of hazardous reactions
Nonflammable
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
Acute toxicity
- Oral: LD50 Rat oral 576-1780 mg/kg
- Inhalation: no data available
- Dermal: LD50 Rabbit percutaneous 1440-3160 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
No degradation of 2,3,6-trichlorophenylacetic acid was observed when incubated with lake water/sediment or activated sludge under aerobic conditions or with a sandy loam soil in water under anaerobic conditions(1). More than 75% of 2,3,6-trichlorophenylacetic acid remained after 120 day biodegradation studies in lake water (Oneida Lake, NY), primary sewage effluent, soil, and soil/water suspensions; adding supplemental nutrients deceases the amount remaining to 40% after 120 days in soil inoculum while little effect was observed using other media. Cometabolic degradation may be the major biodegradation process for 2,3,6-trichlorophenylacetic acid in aquatic systems(2). A dichlorohydroxybenzene derivative was tentatively identified as a product of the biodegradation of 2,3,6-trichlorophenylacetic acid in soil(2). 2,3,6-Trichlorophenylacetic acid was described as being susceptible to decarboxylation reactions when incubated with soil inoculum(3).
Bioaccumulative potential
Experimental bioconcentration factors ranging from 1.6 to 11.6 in bluegills (Lepomis macrochirus) were determined in static tests with a 2,3,6-trichlorophenylacetic acid concentration of 2 ppm(1). Based on an experimental log Kow of 3.20 for 2,3,6-trichlorophenylacetic acid, obtained in 0.1 and 0.5 M HCl(2), and its water solubility, 200 mg/L at 28 deg C(3), estimated bioconcentration factors ranging from 31 to 159 can be calculated(SRC) using an appropriate regression equation(4). The magnitude of these values indicate that bioconcentration in fish and aquatic organisms will not be a significant process(SRC).
Mobility in soil
Experimental soil adsorption coefficients ranging from 0.3 to 667 on four different sediments with percent organic carbon ranging from 0.3 to 54 were observed at pH 6.5; adsorption on organic muck was found to increase at pH 4.5 but not at pH 9(1). Soil pH, especially in the range 5.0-6.7, was described as the most important factor in 2,3,6-trichlorophenylacetic acid mobility(2-3). At neutral or basic pHs, 2,3,6-trichlorophenylacetic acid will exist predominately as the ionized acid and adsorption to soil will driven by ionic interactions between it and the soil while at more acidic pHs hydrophobic processes will predominate(4). Soil TLC experiments using a wide range of soils (Hagerstown silty clay loam, Lakeland sandy loam, Chillium silt loam) produced Rfs ranging from 0.38 to 1.0 indicating that 2,3,6-trichlorophenylacetic acid has a high degree of mobility compared to other pesticides(2-6).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.