N-Nitrosodiphenylamine

Skin sensitization, Sub-category 1A

Carcinogenicity, Category 2

Reproductive toxicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H225 Highly Flammable liquid and vapour

H301 Toxic if swalloed

H302 Harmful if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H320 Causes eye irritation

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H351 Suspected of causing cancer

H370 Causes damage to organs

H371 May cause damage to organs

H373 May cause damage to organs through prolonged or repeated exposure

H411 Toxic to aquatic life with long lasting effects

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash hands thoroughly after handling.

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P311 Call a POISON CENTER or doctor/physician.

P391 Collect spillage. Hazardous to the aquatic environment

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405 Store locked up.

P501 Dispose of contents/container to..…

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P203 Obtain, read and follow all safety instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P318 IF exposed or concerned, get medical advice.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. Nitrates, nitrites, and related compounds

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use foam, powder, carbon dioxide.

Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Decontamination of N-nitrosamine contaminated glassware /was described/. N-nitrosamines

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

MAK: carcinogen category: 3B

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles.

Protective gloves.

Use local exhaust or breathing protection.

no data available

Decomposes on burning. This produces nitrogen oxides. Reacts vigorously with oxidants.

The nitrosamines are stable at neutral pH ... Nitrosamines

N-NITROSODIPHENYLAMINE may be sensitive to moisture at elevated temperatures in strongly acidic solutions. May react vigorously with oxidizing agents. May undergo trans-nitrosation reactions with secondary amines (NTP, 1992).

no data available

no data available

Energy of decomposition (in range 300-500 deg C) measured as 0.65 kJ/g.

no data available

no data available

no data available

no data available

No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

no data available

no data available

no data available

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

The half-life of N-nitrosodiphenylamine in 86 g/kg sludge soil produced from a wood preserving process was determined to be 88.9 days, from an initial concentration of 697 mg/kg and a final concentration of 19 mg/kg after 287 days; the half-life of N-nitrosodiphenylamine in 172 g/kg sludge soil produced from a wood preserving process was determined to be 166.4 days, from an initial concentration of 887 mg/kg and a final concentration of 58 mg/kg after 287 days(1). In a static biodegradation test that used domestic wastewater as the inoculum, the percent of N-nitrosodiphenylamine biodegraded in the original culture and first, second and third subcultures after 7 days incubation per culture was: (10 mg/l initial concentration N-nitrosodiphenylamine) 47, 63, 95, and 98; at 5 mg/l initial concentration N-nitrosodiphenylamine: 87, 100, 92, and 100, respectively(2). Removal of N-nitrosodiphenylamine at two industrial activated sludge treatment plants averaged >84 percent at an average influent concentration of 5.3 ug/l(3). At an industrial aerated lagoon, 67 percent of an initial N-nitrosodiphenylamine concentration of 3 ug/l was removed(3). Sixty-eight percent of N-nitrosodiphenylamine added to soil at a concentration of 354 ug/g soil was degraded by the end of a 30 day incubation at 30 deg C in the dark(3). In soil amended with wheat straw (organic matter content increased from 2.16 to 17.5 percent), N-nitrosodiphenylamine disappeared completely by day 10 of the incubation(4).

A maximum bioconcentration factor (BCF) of 217 was reported for N-nitrosodiphenylamine in Lepomis macrochirus (bluegill sunfish) exposed to an average N-nitrosodiphenylamine concentration of 9.21 ug/l for 14 days(1). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is moderately high(SRC).

The Koc of N-nitrosodiphenylamine is estimated as approximately 1,200(SRC), using an experimental log Kow of 3.13(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that N-nitrosodiphenylamine is expected to have low mobility in soil(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.