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ChemicalBook >> CAS DataBase List >> N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea price.
  • $47 - $7364
  • Product name: N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea
  • CAS: 1020172-07-9
  • MF: C30H28FN7O3
  • MW: 553.59
  • EINECS:
  • MDL Number:MFCD19443646
  • Synonyms:Rebastinib;DCC-2036 (Rebastinib);N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(MethylcarbaMoyl)pyridin-4-yl);1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea;N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea DCC-2036 (Rebastinib);Rebastinib(DCC-2036);N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea;Rebastinib Tosylate
Price28 Properties Safety Information Description
28 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 2x5mg
  • 25mg
  • 50mg
  • 100mg
  • 200MG
  • 250mg
  • 500mg
  • 5g
  • 10mM(in 1mL DMSO)
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7511
  • Product descriptionRebastinib
  • Packaging1g
  • Price$2523
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001381
  • Product descriptionREBASTINIB 95.00%
  • Packaging200MG
  • Price$2800
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1404
  • Product descriptionDCC-2036(Rebastinib)
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1404
  • Product descriptionDCC-2036(Rebastinib)
  • Packaging10mM(in 1mL DMSO)
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1404
  • Product descriptionDCC-2036(Rebastinib)
  • Packaging10mg
  • Price$157
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1404
  • Product descriptionDCC-2036(Rebastinib)
  • Packaging50mg
  • Price$627
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2123
  • Product descriptionDCC2036-Rebastinib 99%
  • Packaging2x5mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146234
  • Product descriptionDCC-2036 (Rebastinib) >98%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146234
  • Product descriptionDCC-2036 (Rebastinib) >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146234
  • Product descriptionDCC-2036 (Rebastinib) >98%
  • Packaging1g
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD64998
  • Product descriptionDCC 2036
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD64998
  • Product descriptionDCC 2036
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD64998
  • Product descriptionDCC 2036
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD64998
  • Product descriptionDCC 2036
  • Packaging250mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD64998
  • Product descriptionDCC 2036
  • Packaging500mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21465
  • Product descriptionRebastinib ≥98%
  • Packaging1mg
  • Price$47
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7511 Rebastinib 1g $2523 2021-12-16 Buy
American Custom Chemicals Corporation INB0001381 REBASTINIB 95.00% 200MG $2800 2021-12-16 Buy
ApexBio Technology B1404 DCC-2036(Rebastinib) 5mg $104 2021-12-16 Buy
ApexBio Technology B1404 DCC-2036(Rebastinib) 10mM(in 1mL DMSO) $121 2021-12-16 Buy
ApexBio Technology B1404 DCC-2036(Rebastinib) 10mg $157 2021-12-16 Buy
ApexBio Technology B1404 DCC-2036(Rebastinib) 50mg $627 2021-12-16 Buy
Axon Medchem Axon2123 DCC2036-Rebastinib 99% 2x5mg $198 2021-12-16 Buy
Biorbyt Ltd orb146234 DCC-2036 (Rebastinib) >98% 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb146234 DCC-2036 (Rebastinib) >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb146234 DCC-2036 (Rebastinib) >98% 1g $2691.1 2021-12-16 Buy
Biosynth Carbosynth FD64998 DCC 2036 10mg $65 2021-12-16 Buy
Biosynth Carbosynth FD64998 DCC 2036 50mg $250 2021-12-16 Buy
Biosynth Carbosynth FD64998 DCC 2036 100mg $400 2021-12-16 Buy
Biosynth Carbosynth FD64998 DCC 2036 250mg $750 2021-12-16 Buy
Biosynth Carbosynth FD64998 DCC 2036 500mg $1000 2021-12-16 Buy
Cayman Chemical 21465 Rebastinib ≥98% 1mg $47 2024-03-01 Buy
Next Last

Properties

Melting point :>181°C (dec.)
Boiling point :666.8±55.0 °C(Predicted)
Density :1.32
storage temp. :-20°C Freezer
solubility :Methanol (Slightly)
pka :12.25±0.70(Predicted)
form :Solid
color :Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rebastinib is an orally bioavailable tyrosine kinase inhibitor that inhibits Abl1 (IC50 = 0.8 nM) as well as the gatekeeper mutant Abl1T315I (IC50 = 4 nM) and the activation loop mutant Abl1H396P. It also inhibits the Src family kinases Src, Lyn, Fgr, and Hck and the tyrosine kinases KDR, FLT3, and Tie2 at nanomolar concentrations. Rebastinib inhibits mutant Abl1T315I signaling and prolongs survival in a mouse Ba/F3 cell allograft model. Rebastinib also exhibits in vivo antineoplastic activity against cells with the T674I point mutation of FIP1-like-1-platelet-derived growth factor receptor α.

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