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ChemicalBook >> CAS DataBase List >> (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

$62 - $5541
Product name: (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
CAS: 1032754-93-0
MF: C23H30N8O3S
MW: 498.6
EINECS:
MDL Number:MFCD20274520
Synonyms:(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one;GNE 390;GDC-0980;(S)-1-(4-((2-(2-aMinopyriMidin-5-yl)-7-Methyl-4-Morpholinothieno[3,2-d]pyriMidin-6-yl)Methyl)piperazin-1-yl)-2-hydroxypropan-1-one;GDC-0980 (RG7422);RG7422;Apitolisib;Apitolisib (GDC-0980, RG7422)

Price28 Properties Safety Information Description

28 prices

Selected condition：

Brand

Adipogen Life Sciences
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC

Package

5mg
10mM(in 1mL DMSO)
1MG
2x5mg
10mg
25MG
50mg
100mg
250mg
1g
5g

ManufacturerAdipogen Life Sciences
Product numberSYN-1150-M005
Product descriptionRG7422 ≥95%
Packaging5mg
Price$162
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberX7458
Product descriptionGDC-0980
Packaging10mg
Price$136
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0001345
Product descriptionGDC-0980 99.00%
Packaging1MG
Price$228.9
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0001345
Product descriptionGDC-0980 99.00%
Packaging5MG
Price$786.5
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0001345
Product descriptionGDC-0980 99.00%
Packaging25MG
Price$1270.5
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2184
Product descriptionGDC-0980(RG7422)
Packaging10mM(in 1mL DMSO)
Price$100
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2184
Product descriptionGDC-0980(RG7422)
Packaging10mg
Price$130
Updated2021-12-16
Buy

ManufacturerArctom
Product numberCFN60254
Product descriptionApitolisib(GDC-0980)
Packaging10mg
Price$238
Updated2021-12-16
Buy

ManufacturerAxon Medchem
Product numberAxon1782
Product descriptionGDC0980-RG7422|GNE390|Apitolisib 99%
Packaging2x5mg
Price$154
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb154688
Product descriptionApitolisib(GDC-0980) >98%
Packaging100mg
Price$615.4
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb154688
Product descriptionApitolisib(GDC-0980) >98%
Packaging250mg
Price$1208.7
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb154688
Product descriptionApitolisib(GDC-0980) >98%
Packaging1g
Price$2395.3
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number18303
Product descriptionGDC-0980 ≥98%
Packaging1mg
Price$62
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number18303
Product descriptionGDC-0980 ≥98%
Packaging5mg
Price$180
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number18303
Product descriptionGDC-0980 ≥98%
Packaging10mg
Price$299
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number18303
Product descriptionGDC-0980 ≥98%
Packaging25mg
Price$595
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Adipogen Life Sciences	SYN-1150-M005	RG7422 ≥95%	5mg	$162	2021-12-16	Buy
AK Scientific	X7458	GDC-0980	10mg	$136	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0001345	GDC-0980 99.00%	1MG	$228.9	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0001345	GDC-0980 99.00%	5MG	$786.5	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0001345	GDC-0980 99.00%	25MG	$1270.5	2021-12-16	Buy
ApexBio Technology	B2184	GDC-0980(RG7422)	10mM(in 1mL DMSO)	$100	2021-12-16	Buy
ApexBio Technology	B2184	GDC-0980(RG7422)	10mg	$130	2021-12-16	Buy
Arctom	CFN60254	Apitolisib(GDC-0980)	10mg	$238	2021-12-16	Buy
Axon Medchem	Axon1782	GDC0980-RG7422\|GNE390\|Apitolisib 99%	2x5mg	$154	2021-12-16	Buy
Biorbyt Ltd	orb154688	Apitolisib(GDC-0980) >98%	100mg	$615.4	2021-12-16	Buy
Biorbyt Ltd	orb154688	Apitolisib(GDC-0980) >98%	250mg	$1208.7	2021-12-16	Buy
Biorbyt Ltd	orb154688	Apitolisib(GDC-0980) >98%	1g	$2395.3	2021-12-16	Buy
Cayman Chemical	18303	GDC-0980 ≥98%	1mg	$62	2024-03-01	Buy
Cayman Chemical	18303	GDC-0980 ≥98%	5mg	$180	2024-03-01	Buy
Cayman Chemical	18303	GDC-0980 ≥98%	10mg	$299	2024-03-01	Buy
Cayman Chemical	18303	GDC-0980 ≥98%	25mg	$595	2024-03-01	Buy

Next Last

Properties

Melting point :>202°C (dec.)
Density :1.399
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.90±0.20(Predicted)
color :White to Light Yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively, in cell-free assays. It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases. GDC-0980 induces cell cycle arrest or apoptosis in a range of cancer cell lines. It is effective in vivo, suppressing the growth of a number of tumor xenografts in mice and enhancing the antitumor activity of docetaxel in mice.

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Suppliers and manufacturers

career henan chemical co

$2.00 /1kg
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one CAS:1032754-93-0

TargetMol Chemicals Inc.

$38.00 /2mg
Apitolisib CAS:1032754-93-0

Capot Chemical Co.,Ltd.

ATK CHEMICAL COMPANY LIMITED

Biochempartner

Hubei xin bonus chemical co. LTD

Chongqing Chemdad Co., Ltd

Alchem Pharmtech,Inc.

CONIER CHEM AND PHARMA LIMITED

HANGZHOU CLAP TECHNOLOGY CO.,LTD

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(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

Properties

Safety Information

Description

Related product price

Suppliers and manufacturers