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ChemicalBook >> CAS DataBase List >> ADX-47273

ADX-47273

ADX-47273 price.
  • $41 - $1805
  • Product name: ADX-47273
  • CAS: 851881-60-2
  • MF: C20H17F2N3O2
  • MW: 369.36
  • EINECS:
  • MDL Number:MFCD17167026
  • Synonyms:ADX-47273;(S)-(4-Fluorophenyl)-{3-[3-(4-fluorophenyl)-[1,2,4]oxadiazol-5-yl]piperidin-1-yl}methanone;BA 94673139;ADX47273, >98%;ADX-47273;ADX47273;CS-221;ADX-47273 >=98% (HPLC);(3S)-3-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(4-fluorophenyl)carbonyl]piperidine
30 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7599
  • Product description(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
  • Packaging10mg
  • Price$164
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7599
  • Product description(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
  • Packaging50mg
  • Price$451
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging5mg
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging10mg
  • Price$66
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging25mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging50mg
  • Price$163
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging100mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging250mg
  • Price$351
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA217506
  • Product descriptionADX-47273 99+%
  • Packaging1g
  • Price$841
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBIO0000304
  • Product descriptionADX-47273 95.00%
  • Packaging5MG
  • Price$495.14
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1632
  • Product descriptionADX-47273
  • Packaging5mg
  • Price$87
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1632
  • Product descriptionADX-47273
  • Packaging10mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1632
  • Product descriptionADX-47273
  • Packaging50mg
  • Price$520
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1632
  • Product descriptionADX-47273
  • Packaging100mg
  • Price$914
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA103122
  • Product descriptionADX 47273
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA103122
  • Product descriptionADX 47273
  • Packaging50mg
  • Price$297.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7599 (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 10mg $164 2021-12-16 Buy
AK Scientific X7599 (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 50mg $451 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 5mg $41 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 10mg $66 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 25mg $125 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 50mg $163 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 100mg $212 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 250mg $351 2021-12-16 Buy
Ambeed A217506 ADX-47273 99+% 1g $841 2021-12-16 Buy
American Custom Chemicals Corporation BIO0000304 ADX-47273 95.00% 5MG $495.14 2021-12-16 Buy
ApexBio Technology B1632 ADX-47273 5mg $87 2021-12-16 Buy
ApexBio Technology B1632 ADX-47273 10mg $139 2021-12-16 Buy
ApexBio Technology B1632 ADX-47273 50mg $520 2021-12-16 Buy
ApexBio Technology B1632 ADX-47273 100mg $914 2021-12-16 Buy
Biosynth Carbosynth FA103122 ADX 47273 10mg $85 2021-12-16 Buy
Biosynth Carbosynth FA103122 ADX 47273 50mg $297.5 2021-12-16 Buy

Properties

Boiling point :540.8±60.0 °C(Predicted)
Density :1.311
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :-0.83±0.44(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

ADX-47273 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with EC50 values of 0.17 and 0.23 μM for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures, respectively. It is selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 when used at concentrations up to 10 μM. In vivo, ADX-47273 (1 and 10 mg/kg, i.p.) increases ERK and CREB phosphorylation in the hippocampus and prefrontal cortex in rats. It decreases the conditioned avoidance response, apomorphine-induced climbing, as well as PCP-, apomorphine-, and amphetamine-induced locomotor activity in rats in a dose-dependent manner, indicating antipsychotic-like activity. ADX-47273 (0.1-50 mg/kg, i.p) improves recall in a novel object recognition test and reduces impulsivity in the 5-choice serial reaction time task (5CSRTT). It also enhances reversal learning in mice in the Morris water maze test.

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