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ChemicalBook >> CAS DataBase List >> 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID

4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID

4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID price.
  • $32 - $1138.78
  • Product name: 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID
  • CAS: 155877-83-1
  • MF: C29H30N2O2
  • MW: 438.56
  • EINECS:
  • MDL Number:MFCD06798318
  • Synonyms:4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID;LE 135;4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-(5H)-benzo[e]naphtho[2.3-b][1.4]diazepine-13-yl)benzoicacid;Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentaMethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-;4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid;4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid
Price21 Properties Safety Information Description
21 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10
  • 1mg
  • 50
  • 10MG
  • 25mg
  • 50MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0000158
  • Product description4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID 95.00%
  • Packaging10MG
  • Price$685.21
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0000158
  • Product description4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID 95.00%
  • Packaging50MG
  • Price$1138.78
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6928
  • Product descriptionLE 135
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6928
  • Product descriptionLE 135
  • Packaging10mg
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14415
  • Product descriptionLE 135 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14415
  • Product descriptionLE 135 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14415
  • Product descriptionLE 135 ≥98%
  • Packaging10mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028469
  • Product descriptionLE 135 98.13%
  • Packaging5mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11247240
  • Product description4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoicacid 95+%
  • Packaging5mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22883
  • Product descriptionLE 135
  • Packaging5mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22883
  • Product descriptionLE 135
  • Packaging10mg
  • Price$148
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22883
  • Product descriptionLE 135
  • Packaging25mg
  • Price$325
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22883
  • Product descriptionLE 135
  • Packaging50mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number59481
  • Product descriptionLE 135
  • Packaging25mg
  • Price$975
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0809
  • Product descriptionLE 135 ≥98% (HPLC)
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0809
  • Product descriptionLE 135 ≥98% (HPLC)
  • Packaging25mg
  • Price$479
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation BRS0000158 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID 95.00% 10MG $685.21 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000158 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID 95.00% 50MG $1138.78 2021-12-16 Buy
ApexBio Technology B6928 LE 135 5mg $112 2021-12-16 Buy
ApexBio Technology B6928 LE 135 10mg $158 2021-12-16 Buy
Cayman Chemical 14415 LE 135 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 14415 LE 135 ≥98% 5mg $100 2024-03-01 Buy
Cayman Chemical 14415 LE 135 ≥98% 10mg $139 2024-03-01 Buy
ChemScene CS-0028469 LE 135 98.13% 5mg $280 2021-12-16 Buy
Crysdot CD11247240 4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoicacid 95+% 5mg $140 2021-12-16 Buy
CSNpharm CSN22883 LE 135 5mg $87 2021-12-16 Buy
CSNpharm CSN22883 LE 135 10mg $148 2021-12-16 Buy
CSNpharm CSN22883 LE 135 25mg $325 2021-12-16 Buy
CSNpharm CSN22883 LE 135 50mg $620 2021-12-16 Buy
Medical Isotopes, Inc. 59481 LE 135 25mg $975 2021-12-16 Buy
Sigma-Aldrich SML0809 LE 135 ≥98% (HPLC) 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML0809 LE 135 ≥98% (HPLC) 25mg $479 2024-03-01 Buy
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Properties

Boiling point :601.3±55.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble15mg/mL, clear
pka :3.02±0.10(Predicted)
form :powder
color :yellow to orange

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

LE 135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Kis = 0.22 and 1.4 μM, respectively). LE 135 inhibits retinoic acid-induced transcriptional activation of RARβ (>70% inhibition at 10 μM), but not RARα, RARγ or retinoid X receptor α. It has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia cells, HL-60, with an IC50 value of 0.2 μM.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
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Aladdin Scientific J & K SCIENTIFIC LTD. 3B Pharmachem (Wuhan) International Co.,Ltd. Nanjing Chemlin Chemical Co., Ltd Sigma-Aldrich EMMX Biotechnology LLC BOC Sciences