N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide
![N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide price.](/CAS/GIF/184036-34-8.gif)
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- $286 - $2273
- Product name: N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide
- CAS: 184036-34-8
- MF: C18H15ClN2O6S2
- MW: 454.9
- EINECS:
- MDL Number:MFCD00945687
- Synonyms:N-(4-chloro-3-methyl-2,3-dihydrooxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide;N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide;N-(4-Chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfo;N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3;N-(4-chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfonamide;D07171;Sitax;N- (4- chloro- 3- Methyl- oxazol- 5- yl)- 2- [2- (6- Methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophen
10 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Chemenu
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
Package
- 5MG
- 10MG
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number9627AA
- Product descriptionN-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
- Packaging1g
- Price$2273
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0009258
- Product descriptionSITAXSENTAN 95.00%
- Packaging5MG
- Price$501.96
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0009258
- Product descriptionSITAXSENTAN 95.00%
- Packaging10MG
- Price$765.45
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM282417
- Product descriptionSitaxsentan 98%
- Packaging50mg
- Price$569
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002886
- Product descriptionsitaxsentan 98+%
- Packaging50mg
- Price$609
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002886
- Product descriptionsitaxsentan 98+%
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN12975
- Product descriptionSitaxsentan
- Packaging10mg
- Price$449
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC22383
- Product descriptionSitaxsentan >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number097954
- Product descriptionN-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+%
- Packaging250mg
- Price$742
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number097954
- Product descriptionN-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+%
- Packaging1g
- Price$1647
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9627AA | N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide | 1g | $2273 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009258 | SITAXSENTAN 95.00% | 5MG | $501.96 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009258 | SITAXSENTAN 95.00% | 10MG | $765.45 | 2021-12-16 | Buy |
| Chemenu | CM282417 | Sitaxsentan 98% | 50mg | $569 | 2021-12-16 | Buy |
| Crysdot | CD31002886 | sitaxsentan 98+% | 50mg | $609 | 2021-12-16 | Buy |
| Crysdot | CD31002886 | sitaxsentan 98+% | 10mg | $286 | 2021-12-16 | Buy |
| CSNpharm | CSN12975 | Sitaxsentan | 10mg | $449 | 2021-12-16 | Buy |
| DC Chemicals | DC22383 | Sitaxsentan >98% | 100mg | $600 | 2021-12-16 | Buy |
| Matrix Scientific | 097954 | N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+% | 250mg | $742 | 2021-12-16 | Buy |
| Matrix Scientific | 097954 | N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+% | 1g | $1647 | 2021-12-16 | Buy |
Properties
Melting point :42-45°
Boiling point :663.9±65.0 °C(Predicted)
Density :1.558
storage temp. :2-8°C
solubility :DMSO
form :Powder
pka :4.96±0.10(Predicted)
Boiling point :663.9±65.0 °C(Predicted)
Density :1.558
storage temp. :2-8°C
solubility :DMSO
form :Powder
pka :4.96±0.10(Predicted)
Safety Information
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Description
Sitaxsentan is a selective endothelin-A (ETA) receptor antagonist launched for the treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity. It is the second ET receptor antagonist to be marketed for this indication behind bosentan. PAH encompasses a heterogeneous group of disorders characterized by inappropriate overactivation of the endothelin system and is characterized by a progressive increase in pulmonary vascular resistance resulting from vascular remodeling, vasoconstriction, and cellular proliferation. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation of ETA and ETB receptors. ETA receptors are found primarily on smooth muscle cells and, when activated, induce vasoconstriction and cellular proliferation. ETB receptors are expressed in both pulmonary vascular endothelial cells and smooth muscle cells, and their activation is associated with the renal and pulmonary clearance of ET.More related product prices
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