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ChemicalBook >> CAS DataBase List >>N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Structure
N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide structure
CAS No.
184036-34-8
Chemical Name:
N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide
Synonyms
Sitax;D07171;sitaxsentan, CID216235;(210421-64-0) sitaxsentan;IPI-1040;SITAXENTAN;TBC-11251;N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3;N-(4-Chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfo;N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1 ,3]dioxol-5-yl)acetyl)thiophene-3-su;N- (4- chloro- 3- Methyl- oxazol- 5- yl)- 2- [2- (6- Methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophen;N-(4-chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfonamide
CBNumber:
CB62130969
Molecular Formula:
C18H15ClN2O6S2
Molecular Weight:
454.9
MDL Number:
MFCD00945687
MOL File:
184036-34-8.mol
Last updated:2024-11-19 20:33:22
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N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Properties

Melting point 42-45°
Boiling point 663.9±65.0 °C(Predicted)
Density 1.558
storage temp. 2-8°C
solubility DMSO
form Powder
pka 4.96±0.10(Predicted)
FDA UNII J9QH779MEM

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0009258 SITAXSENTAN 95.00% 184036-34-8 5MG $501.96 2021-12-16 Buy
Matrix Scientific 097954 N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+% 184036-34-8 250mg $742 2021-12-16 Buy
American Custom Chemicals Corporation API0009258 SITAXSENTAN 95.00% 184036-34-8 10MG $765.45 2021-12-16 Buy
Matrix Scientific 097954 N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide sodium salt95+% 184036-34-8 1g $1647 2021-12-16 Buy
AK Scientific 9627AA N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide 184036-34-8 1g $2273 2021-12-16 Buy
Product number Packaging Price Buy
API0009258 5MG $501.96 Buy
097954 250mg $742 Buy
API0009258 10MG $765.45 Buy
097954 1g $1647 Buy
9627AA 1g $2273 Buy

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Chemical Properties,Uses,Production

Description

Sitaxsentan is a selective endothelin-A (ETA) receptor antagonist launched for the treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity. It is the second ET receptor antagonist to be marketed for this indication behind bosentan. PAH encompasses a heterogeneous group of disorders characterized by inappropriate overactivation of the endothelin system and is characterized by a progressive increase in pulmonary vascular resistance resulting from vascular remodeling, vasoconstriction, and cellular proliferation. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation of ETA and ETB receptors. ETA receptors are found primarily on smooth muscle cells and, when activated, induce vasoconstriction and cellular proliferation. ETB receptors are expressed in both pulmonary vascular endothelial cells and smooth muscle cells, and their activation is associated with the renal and pulmonary clearance of ET.

Originator

Encysive (US)

Definition

ChEBI: Sitaxentan is a member of benzodioxoles.

brand name

Thelin

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide synthesis

117661-72-0
184036-34-8
Synthesis of N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide from 3,4-Methylenedioxy-6-methylbenzyl chloride

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Preparation Products And Raw materials

Raw materials

1008726-80-4 3,4-Methylenedioxy-6-methylbenzyl chloride 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]- 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)-N-Methoxy-N-Methylthiophene-2-carboxaMide

Preparation Products

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39004 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
MedChemexpress LLC 58

View Lastest Price from N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sitaxsentan pictures 2024-11-19 Sitaxsentan
184036-34-8
 US $91.00-346.00 / mg 99.34% 10g TargetMol Chemicals Inc.
Sitaxsentan pictures 2024-11-19 Sitaxsentan
184036-34-8
 US $91.00-346.00 / mg 99.34% 10g TargetMol Chemicals Inc.
  • Sitaxsentan pictures
  • Sitaxsentan
    184036-34-8
  • US $91.00-346.00 / mg
  • 99.34%
  • TargetMol Chemicals Inc.
  • Sitaxsentan pictures
  • Sitaxsentan
    184036-34-8
  • US $91.00-346.00 / mg
  • 99.34%
  • TargetMol Chemicals Inc.

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Spectrum

N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide(184036-34-8)1HNMR

184036-34-8(N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide)Related Search:

N-Methylbenzylamine 2-Methylaminoethanol N-Methyl pyrrole N-Methylbenzamide N-Methyldiethanolamine
N- (4- chloro- 3- methyl- oxazol- 5- yl)- 2- [2- (6- methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophene- 3- sulfonamide Sitaxentan sodium 5-AMINO-3-METHYLISOXAZOLE 5-AMINO-4-CHLORO-3-METHYLISOXAZOLE

1of2

N-(4-chloro-3-methyl-2,3-dihydrooxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide N-(4-Chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfo N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3 N-(4-chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfonamide D07171 Sitax N- (4- chloro- 3- Methyl- oxazol- 5- yl)- 2- [2- (6- Methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophen N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1 ,3]dioxol-5-yl)acetyl)thiophene-3-su N-(4-CHLORO-3-METHYL-1,2-OXAZOL-5-YL)-2-[2-(6-METHYL-1,3-BENZODIOXOL-5-YL)ACETYL]THIOPHENE-3-SULFONAMIDE sitaxsentan, CID216235 3-Thiophenesulfonamide,N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]- IPI-1040;SITAXENTAN;TBC-11251 (210421-64-0) sitaxsentan 184036-34-8 C19H15ClNNaO6S2