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ChemicalBook >> CAS DataBase List >> GLY-PHE BETA-NAPHTHYLAMIDE

GLY-PHE BETA-NAPHTHYLAMIDE

GLY-PHE BETA-NAPHTHYLAMIDE price.
  • $57 - $628.99
  • Product name: GLY-PHE BETA-NAPHTHYLAMIDE
  • CAS: 21438-66-4
  • MF: C21H21N3O2
  • MW: 347.41
  • EINECS:
  • MDL Number:MFCD00021597
  • Synonyms:glycylphenylalanine2-naphthylamide ;GLY-PHE BETA-NAPHTHYLAMIDE;H-GLY-PHE-BETA-NA;gly-phe B-naphthylamide;H-Gly-Phe-bNA;glycyl-L-phenylalanine 2-naphthylamide;gly-phe β-naphthylamide;(S)-N-(2-(2-Aminoacetamido)-3-phenylpropanoyl)-2-naphthamide
7 prices
Selected condition:
Brand
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Chem-Impex
  • Usbiological
Package
  • 5MG
  • 50mg
  • 100mg
  • 500mg
  • 1G
  • ManufacturerAlfa Aesar
  • Product numberJ64718
  • Product descriptionGly-Phe beta-naphthylamide
  • Packaging100mg
  • Price$105
  • Updated2023-06-20
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPEP0004639
  • Product descriptionGLY-PHE BETA-NAPHTHYLAMIDE 95.00%
  • Packaging5MG
  • Price$495.24
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14634
  • Product descriptionGly-Phe-β-naphthylamide ≥95%
  • Packaging50mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14634
  • Product descriptionGly-Phe-β-naphthylamide ≥95%
  • Packaging100mg
  • Price$85
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14634
  • Product descriptionGly-Phe-β-naphthylamide ≥95%
  • Packaging500mg
  • Price$384
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number04564
  • Product descriptionH-Gly-Phe-βNA
  • Packaging1G
  • Price$628.99
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number164304
  • Product descriptionGly-Phe beta-naphthylamide
  • Packaging100mg
  • Price$403
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J64718 Gly-Phe beta-naphthylamide 100mg $105 2023-06-20 Buy
American Custom Chemicals Corporation PEP0004639 GLY-PHE BETA-NAPHTHYLAMIDE 95.00% 5MG $495.24 2021-12-16 Buy
Cayman Chemical 14634 Gly-Phe-β-naphthylamide ≥95% 50mg $57 2024-03-01 Buy
Cayman Chemical 14634 Gly-Phe-β-naphthylamide ≥95% 100mg $85 2024-03-01 Buy
Cayman Chemical 14634 Gly-Phe-β-naphthylamide ≥95% 500mg $384 2024-03-01 Buy
Chem-Impex 04564 H-Gly-Phe-βNA 1G $628.99 2021-12-16 Buy
Usbiological 164304 Gly-Phe beta-naphthylamide 100mg $403 2021-12-16 Buy

Properties

Boiling point :692.4±55.0 °C(Predicted)
Density :1.254±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in 100mg in 200µl DMSO.
form :crystalline
pka :13.62±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Description

Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins. Gly-Phe-β-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. At 50 μM, Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.

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