(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
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- $50 - $4230
- Product name: (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
- CAS: 273404-37-8
- MF: C24H33ClN4O6
- MW: 508.99
- EINECS:
- MDL Number:MFCD11100350
- Synonyms:(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide;Belnacasan (VX765);N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide;L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-;(S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrah;N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide VX 765;VX-765(Belnacasan);CS-387
33 prices
Selected condition：
Brand
- AccelPharmtech
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Ark Pharm
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10MG
- 25MG
- 50mg
- 100mg
- 250mg
- 500mg
- 1G
- ManufacturerAccelPharmtech
- Product numberLX1651
- Product description(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00%
- Packaging25MG
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0257
- Product descriptionVX-765
- Packaging50mg
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0257
- Product descriptionVX-765
- Packaging250mg
- Price$1501
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000874
- Product descriptionVX-765 99.00%
- Packaging5MG
- Price$460
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000874
- Product descriptionVX-765 99.00%
- Packaging10MG
- Price$484
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000874
- Product descriptionVX-765 99.00%
- Packaging50MG
- Price$613
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000874
- Product descriptionVX-765 99.00%
- Packaging1G
- Price$4230
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8238
- Product descriptionVX-765
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8238
- Product descriptionVX-765
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60139
- Product descriptionBelnacasan(VX-765) ≥98%
- Packaging10mg
- Price$238
- Updated2021-12-16
- Buy
- ManufacturerArk Pharm
- Product numberP000532862
- Product descriptionVX-765 98+%
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerArk Pharm
- Product numberP000532862
- Product descriptionVX-765 98+%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerArk Pharm
- Product numberP000532862
- Product descriptionVX-765 98+%
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerArk Pharm
- Product numberP000532862
- Product descriptionVX-765 98+%
- Packaging50mg
- Price$521
- Updated2021-12-16
- Buy
- ManufacturerArk Pharm
- Product numberP000532862
- Product descriptionVX-765 98+%
- Packaging100mg
- Price$852
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFV137735
- Product descriptionVX 765
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | LX1651 | (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00% | 25MG | $240 | 2021-12-16 | Buy |
| AK Scientific | Y0257 | VX-765 | 50mg | $498 | 2021-12-16 | Buy |
| AK Scientific | Y0257 | VX-765 | 250mg | $1501 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000874 | VX-765 99.00% | 5MG | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000874 | VX-765 99.00% | 10MG | $484 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000874 | VX-765 99.00% | 50MG | $613 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000874 | VX-765 99.00% | 1G | $4230 | 2021-12-16 | Buy |
| ApexBio Technology | A8238 | VX-765 | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A8238 | VX-765 | 100mg | $450 | 2021-12-16 | Buy |
| Arctom | CFN60139 | Belnacasan(VX-765) ≥98% | 10mg | $238 | 2021-12-16 | Buy |
| Ark Pharm | P000532862 | VX-765 98+% | 1mg | $50 | 2021-12-16 | Buy |
| Ark Pharm | P000532862 | VX-765 98+% | 5mg | $120 | 2021-12-16 | Buy |
| Ark Pharm | P000532862 | VX-765 98+% | 10mg | $160 | 2021-12-16 | Buy |
| Ark Pharm | P000532862 | VX-765 98+% | 50mg | $521 | 2021-12-16 | Buy |
| Ark Pharm | P000532862 | VX-765 98+% | 100mg | $852 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FV137735 | VX 765 | 10mg | $95 | 2021-12-16 | Buy |
Properties
Boiling point :779.0±60.0 °C(Predicted)
Density :1.32
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :12.60±0.40(Predicted)
color :Off-white to white
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.32
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :12.60±0.40(Predicted)
color :Off-white to white
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.1 VRT-043198 ICE/caspase-1 IC50 = 0.67 μM PBMCs, 1.0 μM whole blood.? It inhibited the release of IL-1b and IL-18 from human monocytes in vitro and their production in vivo in models of inflammation. Belnacasan inhibited the activation and expression of the NLRP3 Inflammasome leading to moderation of depressive-like behaviors induced by chronic mild stress2 and prevention of glial pyroptosis in multiple sclerosis models3. It inhibited pyroptosis in vascular smooth muscle cells during atherogenesis suggesting a possible therapeutic effect in treating atherosclerotic disease.4 Belnacasan reduced acute seizures and drug resistant chronic epileptic activity in mice5 and provided neuroprotection in two rat models of temporal lobe epilepsy6.? It also displays protective effects in models of stroke7and Alzheimer’s disease8.Related product price
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