3-AP
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- $32 - $2395.3
- Product name: 3-AP
- CAS: 143621-35-6
- MF: C7H9N5S
- MW: 195.24
- EINECS:
- MDL Number:MFCD00924747
- Synonyms:3-Apct;C078157;Pan 811;Pan811;Pan-811;Triapine;2-((3-AMinopyridin-2-yl)Methylene)hydrazinecarbothioaMide;NSC 663249
29 prices
Selected condition:
Brand
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerApexBio Technology
- Product numberC4564
- Product description3-AP
- Packaging5mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4564
- Product description3-AP
- Packaging10mg
- Price$137
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4564
- Product description3-AP
- Packaging25mg
- Price$303
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging10mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging25mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging50mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging100mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging250mg
- Price$246
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS528850
- Product descriptionTriapine ≥98%
- Packaging1g
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181340
- Product descriptionTriapine >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181340
- Product descriptionTriapine >98%
- Packaging250mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181340
- Product descriptionTriapine >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15419
- Product description3-AP ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15419
- Product description3-AP ≥95%
- Packaging5mg
- Price$70
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15419
- Product description3-AP ≥95%
- Packaging10mg
- Price$120
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
ApexBio Technology | C4564 | 3-AP | 5mg | $78 | 2021-12-16 | Buy |
ApexBio Technology | C4564 | 3-AP | 10mg | $137 | 2021-12-16 | Buy |
ApexBio Technology | C4564 | 3-AP | 25mg | $303 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 5mg | $41 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 10mg | $52 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 25mg | $88 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 50mg | $115 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 100mg | $165 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 250mg | $246 | 2021-12-16 | Buy |
Arctom | AS528850 | Triapine ≥98% | 1g | $640 | 2021-12-16 | Buy |
Biorbyt Ltd | orb181340 | Triapine >98% | 100mg | $838.1 | 2021-12-16 | Buy |
Biorbyt Ltd | orb181340 | Triapine >98% | 250mg | $1431.4 | 2021-12-16 | Buy |
Biorbyt Ltd | orb181340 | Triapine >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
Cayman Chemical | 15419 | 3-AP ≥95% | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 15419 | 3-AP ≥95% | 5mg | $70 | 2024-03-01 | Buy |
Cayman Chemical | 15419 | 3-AP ≥95% | 10mg | $120 | 2024-03-01 | Buy |
Properties
Melting point :234 °C
Boiling point :436.0±55.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10Meq/mL, clear
pka :10.93±0.70(Predicted)
form :powder
color :white to light brown
CAS DataBase Reference :143621-35-6
Boiling point :436.0±55.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10Meq/mL, clear
pka :10.93±0.70(Predicted)
form :powder
color :white to light brown
CAS DataBase Reference :143621-35-6
Safety Information
Symbol(GHS): |
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Description
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.More related product prices
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- 143621-35-6
$32-2395.3