(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE
![(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE price.](/CAS/GIF/477575-56-7.gif)
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- $49 - $2400
- Product name: (2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE
- CAS: 477575-56-7
- MF: C32H34Cl2N4O4S
- MW: 641.61
- EINECS:
- MDL Number:MFCD07772270
- Synonyms:PHA 665752;(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE;(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE PHA 665752;PHA-665752/PHA665752;(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one;PHA 665752 (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine;(R,Z)-5-((2,6-Dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin;(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE USP/EP/BP
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 10MG
- 25mg
- 50MG
- 100mg
- 250mg
- 50
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product number2650AH
- Product description(3Z)-5-[(2,6-Dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
- Packaging1mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000322
- Product descriptionPHA-665752 95.00%
- Packaging10MG
- Price$811.34
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000322
- Product descriptionPHA-665752 95.00%
- Packaging50MG
- Price$1703.92
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- Packaging50mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60170
- Product descriptionPHA-665752 ≥98%
- Packaging10mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181085
- Product descriptionPHA-665752 >98%
- Packaging100mg
- Price$578
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181085
- Product descriptionPHA-665752 >98%
- Packaging250mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181085
- Product descriptionPHA-665752 >98%
- Packaging1000mg
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP71590
- Product descriptionPHA 665752
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP71590
- Product descriptionPHA 665752
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14703
- Product descriptionPHA 665752 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14703
- Product descriptionPHA 665752 ≥98%
- Packaging5mg
- Price$77
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14703
- Product descriptionPHA 665752 ≥98%
- Packaging10mg
- Price$134
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14703
- Product descriptionPHA 665752 ≥98%
- Packaging25mg
- Price$286
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0137
- Product descriptionPHA-665752 99.09%
- Packaging10mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0137
- Product descriptionPHA-665752 99.09%
- Packaging50mg
- Price$396
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2650AH | (3Z)-5-[(2,6-Dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one | 1mg | $101 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000322 | PHA-665752 95.00% | 10MG | $811.34 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000322 | PHA-665752 95.00% | 50MG | $1703.92 | 2021-12-16 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | 50mg | $330 | 2021-12-16 | Buy |
| Arctom | CFN60170 | PHA-665752 ≥98% | 10mg | $188 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181085 | PHA-665752 >98% | 100mg | $578 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181085 | PHA-665752 >98% | 250mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181085 | PHA-665752 >98% | 1000mg | $2245.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP71590 | PHA 665752 | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP71590 | PHA 665752 | 50mg | $437.5 | 2021-12-16 | Buy |
| Cayman Chemical | 14703 | PHA 665752 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 14703 | PHA 665752 ≥98% | 5mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 14703 | PHA 665752 ≥98% | 10mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 14703 | PHA 665752 ≥98% | 25mg | $286 | 2024-03-01 | Buy |
| ChemScene | CS-0137 | PHA-665752 99.09% | 10mg | $98 | 2021-12-16 | Buy |
| ChemScene | CS-0137 | PHA-665752 99.09% | 50mg | $396 | 2021-12-16 | Buy |
Properties
Boiling point :890.2±65.0 °C(Predicted)
Density :1.404
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.39±0.20(Predicted)
color :light yellow to light brown
optical activity :[α]/D +50 to +70°, c = 0.2 in methanol
Density :1.404
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.39±0.20(Predicted)
color :light yellow to light brown
optical activity :[α]/D +50 to +70°, c = 0.2 in methanol
Safety Information
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Description
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA 665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM; IC50 = 9 nM). It exhibits >50-fold selectivity for c-Met over a panel of tyrosine and serine/threonine kinases. PHA 665752 can inhibit c-Met phosphorylation, as well as cell proliferation and cell motility, of various tumor cells (IC50s = 18-50 nM). It also inhibits signal transduction downstream of c-Met, interfering with the activation of Gab-1 adaptor protein, ERK1/2, Akt, STAT3, PLC-γ, and focal adhesion kinase in multiple tumor cell lines. In a gastric carcinoma xenograft model, 25 mg/kg PHA-665752 was shown to reduce tumor growth in mice by inhibiting c-Met activation.More related product prices
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![(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE](https://img.chemicalbook.com/ProductImageEN/2019-8/small/60815b71-4364-4233-9e47-c21f80d5fd5d.png){kind=small}