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ChemicalBook >> CAS DataBase List >> 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione price.
  • $32 - $2245.7
  • Product name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • CAS: 648450-29-7
  • MF: C12H7N3O2S
  • MW: 257.27
  • EINECS:
  • MDL Number:MFCD11100415
  • Synonyms:5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;AS605240;5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, >=98%;(E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-;AS-605240(AS 605240)
42 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 20mg
  • 10
  • 25mg
  • 250mg
  • 1000mg
  • 50
  • 10mM(in 1mL DMSO)
  • 1MG
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 500mg
  • ManufacturerAK Scientific
  • Product numberX7408
  • Product description5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • Packaging500mg
  • Price$1300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA108127
  • Product description5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+%
  • Packaging5mg
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA108127
  • Product description5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+%
  • Packaging10mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA108127
  • Product description5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+%
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA108127
  • Product description5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+%
  • Packaging100mg
  • Price$363
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000848
  • Product descriptionAS-605240 95.00%
  • Packaging1MG
  • Price$569.99
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000848
  • Product descriptionAS-605240 95.00%
  • Packaging5MG
  • Price$686.07
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000848
  • Product descriptionAS-605240 95.00%
  • Packaging10MG
  • Price$739.78
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5176
  • Product descriptionAS-605240
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5176
  • Product descriptionAS-605240
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5176
  • Product descriptionAS-605240
  • Packaging50mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5176
  • Product descriptionAS-605240
  • Packaging100mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIFK0058
  • Product descriptionAS605240,FreeBase 98%
  • Packaging5mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIFK0058
  • Product descriptionAS605240,FreeBase 98%
  • Packaging10mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIFK0058
  • Product descriptionAS605240,FreeBase 98%
  • Packaging50mg
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60362
  • Product descriptionAS-605240 ≥98%
  • Packaging20mg
  • Price$238
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7408 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione 500mg $1300 2021-12-16 Buy
Ambeed A108127 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+% 5mg $128 2021-12-16 Buy
Ambeed A108127 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+% 10mg $166 2021-12-16 Buy
Ambeed A108127 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+% 50mg $280 2021-12-16 Buy
Ambeed A108127 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione 98+% 100mg $363 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000848 AS-605240 95.00% 1MG $569.99 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000848 AS-605240 95.00% 5MG $686.07 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000848 AS-605240 95.00% 10MG $739.78 2021-12-16 Buy
ApexBio Technology A5176 AS-605240 10mg $50 2021-12-16 Buy
ApexBio Technology A5176 AS-605240 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A5176 AS-605240 50mg $195 2021-12-16 Buy
ApexBio Technology A5176 AS-605240 100mg $280 2021-12-16 Buy
Apolloscientific BIFK0058 AS605240,FreeBase 98% 5mg $73 2021-12-16 Buy
Apolloscientific BIFK0058 AS605240,FreeBase 98% 10mg $109 2021-12-16 Buy
Apolloscientific BIFK0058 AS605240,FreeBase 98% 50mg $254 2021-12-16 Buy
Arctom CFN60362 AS-605240 ≥98% 20mg $238 2021-12-16 Buy

Properties

Density :1.553±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :6.02±0.20(Predicted)
form :powder
color :, faint red to orange to dark brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

PI 3-Kγ Inhibitor is a cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of PI 3-kinase γ (PI 3-Kγ) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively). PI 3-Kγ Inhibitor does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 μM. It selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). PI 3-Kγ Inhibitor has also been shown to exhibit efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.

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