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ChemicalBook >> CAS DataBase List >> (5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID

(5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID

(5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID price.
  • $165 - $5849.55
  • Product name: (5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID
  • CAS: 79516-82-8
  • MF: C20H32O5
  • MW: 352.47
  • EINECS:
  • MDL Number:MFCD00065858
  • Synonyms:hydroxyleukotriene B4;(5R,12S,6Z,8E,10E,14Z)-5,12,20-Trihydroxy-6,8,10,14-icosatetraenoic acid;20-OH-LTB4;20-HYDROXYLEUKOTRIENE B4;5S,12R,20-TRIHYDROXY-6Z,8E,10E,14Z-EICOSATETRAENOIC ACID;(5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID;PTJFJXLGRSTECQ-PSPARDEHSA-N;6,8,10,14-Eicosatetraenoic acid, 5,12,20-trihydroxy-, (5S,6Z,8E,10E,12R,14Z)-
6 prices
Selected condition:
Brand
  • AHH
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 25μg
  • 50μg
  • 0.0001g
  • 100μg
  • 1MG
  • ManufacturerAHH
  • Product numberMT-15150
  • Product description20-HydroxyleukotrieneB4 97%
  • Packaging0.0001g
  • Price$445
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0007226
  • Product description(5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID 95.00%
  • Packaging1MG
  • Price$5849.55
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20190
  • Product description20-hydroxy Leukotriene B4 ≥97%
  • Packaging25μg
  • Price$165
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20190
  • Product description20-hydroxy Leukotriene B4 ≥97%
  • Packaging50μg
  • Price$311
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20190
  • Product description20-hydroxy Leukotriene B4 ≥97%
  • Packaging100μg
  • Price$587
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberG377488
  • Product description20-OH-LTB4
  • Packaging1mg
  • Price$1680
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-15150 20-HydroxyleukotrieneB4 97% 0.0001g $445 2021-12-16 Buy
American Custom Chemicals Corporation CCH0007226 (5S,12R)-5,12,20-TRIHYDROXY-(6Z,8E,10E,14Z)-EICOSATETRAENOIC ACID 95.00% 1MG $5849.55 2021-12-16 Buy
Cayman Chemical 20190 20-hydroxy Leukotriene B4 ≥97% 25μg $165 2024-03-01 Buy
Cayman Chemical 20190 20-hydroxy Leukotriene B4 ≥97% 50μg $311 2024-03-01 Buy
Cayman Chemical 20190 20-hydroxy Leukotriene B4 ≥97% 100μg $587 2024-03-01 Buy
TRC G377488 20-OH-LTB4 1mg $1680 2021-12-16 Buy

Properties

Boiling point :581.8±50.0 °C(Predicted)
Density :1.097±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
pka :4.66±0.10(Predicted)
form :Clear to light-yellow liquid.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.

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