5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
![5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one price.](/CAS/20200119/GIF/877636-42-5.gif)
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- $45 - $1600
- Product name: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
- CAS: 877636-42-5
- MF: C17H11N3O6S
- MW: 385.35
- EINECS:
- MDL Number:
- Synonyms:5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one;ML221;ML221; ML 221; ML-221;CS-2842;ML 221;ML-221;4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-;ML221 >=98% (HPLC);4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate
25 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 1mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number8232CQ
- Product description4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl4-nitrobenzoate
- Packaging5mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5282
- Product descriptionML221
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5702
- Product descriptionML221
- Packaging50mg
- Price$819
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5702
- Product descriptionML221
- Packaging100mg
- Price$1449
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5702
- Product descriptionML221
- Packaging5mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5702
- Product descriptionML221
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5702
- Product descriptionML221
- Packaging25mg
- Price$457
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27313
- Product descriptionML-221
- Packaging50mg
- Price$475
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27313
- Product descriptionML-221
- Packaging25mg
- Price$254
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27313
- Product descriptionML-221
- Packaging5mg
- Price$65
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27313
- Product descriptionML-221
- Packaging10mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31004955
- Product descriptionML221 97%
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004955
- Product descriptionML221 97%
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004955
- Product descriptionML221 97%
- Packaging25mg
- Price$181
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004955
- Product descriptionML221 97%
- Packaging50mg
- Price$277
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004955
- Product descriptionML221 97%
- Packaging100mg
- Price$436
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8232CQ | 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl4-nitrobenzoate | 5mg | $170 | 2021-12-16 | Buy |
| AK Scientific | SYN5282 | ML221 | 50mg | $547 | 2021-12-16 | Buy |
| ApexBio Technology | B5702 | ML221 | 50mg | $819 | 2021-12-16 | Buy |
| ApexBio Technology | B5702 | ML221 | 100mg | $1449 | 2021-12-16 | Buy |
| ApexBio Technology | B5702 | ML221 | 5mg | $134 | 2021-12-16 | Buy |
| ApexBio Technology | B5702 | ML221 | 10mg | $221 | 2021-12-16 | Buy |
| ApexBio Technology | B5702 | ML221 | 25mg | $457 | 2021-12-16 | Buy |
| Cayman Chemical | 27313 | ML-221 | 50mg | $475 | 2024-03-01 | Buy |
| Cayman Chemical | 27313 | ML-221 | 25mg | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 27313 | ML-221 | 5mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 27313 | ML-221 | 10mg | $109 | 2024-03-01 | Buy |
| Crysdot | CD31004955 | ML221 97% | 10mg | $80 | 2021-12-16 | Buy |
| Crysdot | CD31004955 | ML221 97% | 5mg | $45 | 2021-12-16 | Buy |
| Crysdot | CD31004955 | ML221 97% | 25mg | $181 | 2021-12-16 | Buy |
| Crysdot | CD31004955 | ML221 97% | 50mg | $277 | 2021-12-16 | Buy |
| Crysdot | CD31004955 | ML221 97% | 100mg | $436 | 2021-12-16 | Buy |
Properties
Boiling point :624.1±55.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :0.30±0.33(Predicted)
form :powder
color :white to beige
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :0.30±0.33(Predicted)
form :powder
color :white to beige
Safety Information
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Description
ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 μM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 μM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively). It inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells when used at concentrations ranging from 5 to 15 μM. In vivo, ML-221 (150 μg/kg) reduces tumor growth in a Mz-ChA-1 mouse xenograft model. Intrathecal injection of ML-221 (10 μg per animal) reduces mechanical allodynia and heat hyperalgesia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. ML-221 also inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy.Suppliers and manufacturers
career henan chemical co
![5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one](https://img.chemicalbook.com/ProductImageEN/2020-1/small/666cff23-51c7-49f5-a336-a34eda87aa4b.png)
ATK CHEMICAL COMPANY LIMITED
Chemia Biotechnology（Shanghai） Co., Ltd
InvivoChem
LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.
Aladdin Scientific
Shanghai Lollane Biological Technology Co.,Ltd.
EMMX Biotechnology LLC
Shanghai EFE Biological Technology Co., Ltd.
$9.80 /1.79999995231628KG
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one CAS:877636-42-5
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one CAS:877636-42-5