AST 487
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- $33 - $1576.85
- Product name: AST 487
- CAS: 630124-46-8
- MF: C26H30F3N7O2
- MW: 529.56
- EINECS:205-525-8
- MDL Number:MFCD11983171
- Synonyms:AST 487;NVP-AST 487;1-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-(4-{[6-(methylamino)-4-pyrimidinyl]oxy}phenyl)urea;1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea;AST487 (NVP- AST487);N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea;Urea,N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-;CS-562
25 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 5mg
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1210-M001
- Product descriptionAST-487 ≥95%
- Packaging1mg
- Price$97
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1210-M050
- Product descriptionAST-487 ≥95%
- Packaging50mg
- Price$972
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1210
- Product descriptionAST-48
- Packaging50mg
- Price$1576.85
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248926
- Product description1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%
- Packaging5mg
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248926
- Product description1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%
- Packaging10mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013792
- Product descriptionAST-487 95.00%
- Packaging1MG
- Price$216.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013792
- Product descriptionAST-487 95.00%
- Packaging5MG
- Price$499.79
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3194
- Product descriptionAST487
- Packaging5mg
- Price$256
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3194
- Product descriptionAST487
- Packaging10mM(in 1mL DMSO)
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3194
- Product descriptionAST487
- Packaging10mg
- Price$462
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3194
- Product descriptionAST487
- Packaging50mg
- Price$925
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19477
- Product descriptionAST-487 ≥98%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19477
- Product descriptionAST-487 ≥98%
- Packaging5mg
- Price$112
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19477
- Product descriptionAST-487 ≥98%
- Packaging10mg
- Price$208
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19477
- Product descriptionAST-487 ≥98%
- Packaging25mg
- Price$475
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0779
- Product descriptionAST487 99.20%
- Packaging5mg
- Price$306
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1210-M001 | AST-487 ≥95% | 1mg | $97 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1210-M050 | AST-487 ≥95% | 50mg | $972 | 2021-12-16 | Buy |
| AK Scientific | SYN1210 | AST-48 | 50mg | $1576.85 | 2021-12-16 | Buy |
| Ambeed | A248926 | 1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+% | 5mg | $253 | 2021-12-16 | Buy |
| Ambeed | A248926 | 1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+% | 10mg | $455 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013792 | AST-487 95.00% | 1MG | $216.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013792 | AST-487 95.00% | 5MG | $499.79 | 2021-12-16 | Buy |
| ApexBio Technology | A3194 | AST487 | 5mg | $256 | 2021-12-16 | Buy |
| ApexBio Technology | A3194 | AST487 | 10mM(in 1mL DMSO) | $430 | 2021-12-16 | Buy |
| ApexBio Technology | A3194 | AST487 | 10mg | $462 | 2021-12-16 | Buy |
| ApexBio Technology | A3194 | AST487 | 50mg | $925 | 2021-12-16 | Buy |
| Cayman Chemical | 19477 | AST-487 ≥98% | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 19477 | AST-487 ≥98% | 5mg | $112 | 2024-03-01 | Buy |
| Cayman Chemical | 19477 | AST-487 ≥98% | 10mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 19477 | AST-487 ≥98% | 25mg | $475 | 2024-03-01 | Buy |
| ChemScene | CS-0779 | AST487 99.20% | 5mg | $306 | 2021-12-16 | Buy |
Properties
Melting point :162-164°C
Boiling point :563.1±50.0 °C(Predicted)
Density :1.341±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.33±0.70(Predicted)
form :Solid
color :White to Light Yellow
Boiling point :563.1±50.0 °C(Predicted)
Density :1.341±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.33±0.70(Predicted)
form :Solid
color :White to Light Yellow
Safety Information
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Description
AST-487 is an inhibitor of RET (IC50 = 0.88 μM), FLT3 (Ki = 0.52 μM), KDR (IC50 = 0.17 μM), c-Abl (IC50 = 0.02 μM), and c-Kit (IC50 = 0.5 μM). It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.More related product prices
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