Ataciguat
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- $81 - $2000
- Product name: Ataciguat
- CAS: 254877-67-3
- MF: C21H19Cl2N3O6S3
- MW: 576.5
- EINECS:
- MDL Number:MFCD09837865
- Synonyms:5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide;Ataciguat;HMR 1766;Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-;Ataciguat (HMR-1766;cyclase,soluble,HMR 1766,Ataciguat,Guanylate Cyclase,Inhibitor,sGC,inhibit,HMR1766,vasodilator,cGMP,guanylate;5-Chloro-2-(5-chlorothiophene-2-sulfonamido)-N-(4-(morpholinosulfonyl)phenyl)benzamide
10 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Crysdot
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 100mg
- ManufacturerAK Scientific
- Product number3142AL
- Product descriptionAtaciguat
- Packaging5mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4216
- Product descriptionAtaciguat
- Packaging10mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18005
- Product descriptionAtaciguat
- Packaging5mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18005
- Product descriptionAtaciguat
- Packaging25mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16371
- Product descriptionAtaciguat ≥95%
- Packaging1mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16371
- Product descriptionAtaciguat ≥95%
- Packaging5mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16371
- Product descriptionAtaciguat ≥95%
- Packaging10mg
- Price$632
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD11158196
- Product descriptionAtaciguat 95+%
- Packaging100mg
- Price$612
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number6932
- Product descriptionAtaciguat
- Packaging10mg
- Price$2000
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA790040
- Product descriptionAtaciguat
- Packaging5mg
- Price$290
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3142AL | Ataciguat | 5mg | $286 | 2021-12-16 | Buy |
| ApexBio Technology | C4216 | Ataciguat | 10mg | $720 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18005 | Ataciguat | 5mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18005 | Ataciguat | 25mg | $375 | 2021-12-16 | Buy |
| Cayman Chemical | 16371 | Ataciguat ≥95% | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16371 | Ataciguat ≥95% | 5mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 16371 | Ataciguat ≥95% | 10mg | $632 | 2024-03-01 | Buy |
| Crysdot | CD11158196 | Ataciguat 95+% | 100mg | $612 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 6932 | Ataciguat | 10mg | $2000 | 2021-12-16 | Buy |
| TRC | A790040 | Ataciguat | 5mg | $290 | 2021-12-16 | Buy |
Properties
Density :1.613±0.06 g/cm3(Predicted)
solubility :DMF: 1 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
form :A crystalline solid
pka :5.70±0.50(Predicted)
color :White to off-white
solubility :DMF: 1 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
form :A crystalline solid
pka :5.70±0.50(Predicted)
color :White to off-white
Safety Information
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Description
Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte recruitment, and platelet aggregation. Oxidation of the heme results in its dissociation from sGC and an impairment of NO signaling, which has been linked to hypertension, hyperlidemia, cardiovascular disease, and diabetes. Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of sGC (EC50 = 0.5-10 μM in purified bovine lung or crude human corpus cavernosum isolates) by binding to the heme pocket and mimicking its function. It has been shown to increase cGMP levels in cultured rat aorta smooth muscle cells and to induce vasorelaxation of isolated rat aorta, porcine coronary arteries, and human corpus cavernosum (EC50 = 1-10 μM).More related product prices
Related product price
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