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ChemicalBook >> CAS DataBase List >> CAY10603

CAY10603

CAY10603 price.
  • $48 - $2200
  • Product name: CAY10603
  • CAS: 1045792-66-2
  • MF: C22H30N4O6
  • MW: 446.5
  • EINECS:
  • MDL Number:MFCD17010286
  • Synonyms:N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester;HDAC6 inhibitor ISOX;CAY10603;Isox;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate;HDAC6 Inhibitor;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;CAY10603; CAY-10603; CAY 10603.
23 prices
Selected condition:
Brand
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 500μg
  • 1000μg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging1mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4856
  • Product descriptionCAY10603
  • Packaging25mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1645
  • Product descriptionHDAC6inhibitorISOX 99%
  • Packaging25mg
  • Price$346.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH138524
  • Product descriptionHistone deacetylase inhibitor VIII
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFH138524
  • Product descriptionHistone deacetylase inhibitor VIII
  • Packaging50mg
  • Price$438
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13146
  • Product descriptionCAY10603 ≥95%
  • Packaging1mg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13146
  • Product descriptionCAY10603 ≥95%
  • Packaging5mg
  • Price$176
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13146
  • Product descriptionCAY10603 ≥95%
  • Packaging10mg
  • Price$324
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13146
  • Product descriptionCAY10603 ≥95%
  • Packaging25mg
  • Price$578
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM191018
  • Product descriptiontert-butyl(4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
  • Packaging100mg
  • Price$842
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3491
  • Product descriptionCAY10603 95.39%
  • Packaging1mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3491
  • Product descriptionCAY10603 95.39%
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3491
  • Product descriptionCAY10603 95.39%
  • Packaging10mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3491
  • Product descriptionCAY10603 95.39%
  • Packaging25mg
  • Price$420
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B4856 CAY10603 1mg $60 2021-12-16 Buy
ApexBio Technology B4856 CAY10603 5mg $105 2021-12-16 Buy
ApexBio Technology B4856 CAY10603 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology B4856 CAY10603 25mg $340 2021-12-16 Buy
Axon Medchem Axon1645 HDAC6inhibitorISOX 99% 25mg $346.5 2021-12-16 Buy
Biosynth Carbosynth FH138524 Histone deacetylase inhibitor VIII 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FH138524 Histone deacetylase inhibitor VIII 50mg $438 2021-12-16 Buy
Cayman Chemical 13146 CAY10603 ≥95% 1mg $48 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 5mg $176 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 10mg $324 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 25mg $578 2024-03-01 Buy
Chemenu CM191018 tert-butyl(4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98% 100mg $842 2021-12-16 Buy
ChemScene CS-3491 CAY10603 95.39% 1mg $72 2021-12-16 Buy
ChemScene CS-3491 CAY10603 95.39% 5mg $132 2021-12-16 Buy
ChemScene CS-3491 CAY10603 95.39% 10mg $216 2021-12-16 Buy
ChemScene CS-3491 CAY10603 95.39% 25mg $420 2021-12-16 Buy

Properties

Density :1.231±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form :Beige to light brown solid
pka :9.47±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

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