DIBENZAZEPINE
|
- $28 - $6428
- Product name: DIBENZAZEPINE
- CAS: 209984-56-5
- MF: C26H23F2N3O3
- MW: 463.48
- EINECS:
- MDL Number:MFCD12828734
- Synonyms:DIBENZAZEPINE;N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;Dibenzazepine (Deshydroxy LY 411575);YO01027;γ-Secretase Inhibitor XX;YO-01027/Dibenzazepine/LY 411575;(2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7-;(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7
39 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 500μg
- 1unit
- 10mM(in 1mL DMSO)
- 1mg
- 2mg
- 3mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5291
- Product descriptionDeshydroxy LY-411575
- Packaging10mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7602
- Product descriptionN-[(1s)-2-[[(7s)-6,7-dihydro-5-methyl-6-oxo-5h-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluro-benzeneacetamide
- Packaging1g
- Price$6428
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ64904
- Product descriptiongamma-Secretase Inhibitor XX
- Packaging3mg
- Price$761
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA457173
- Product descriptionYO-01027 95+%
- Packaging2mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA457173
- Product descriptionYO-01027 95+%
- Packaging5mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA457173
- Product descriptionYO-01027 95+%
- Packaging10mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA457173
- Product descriptionYO-01027 95+%
- Packaging25mg
- Price$388
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging10mM(in 1mL DMSO)
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging25mg
- Price$379
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4018
- Product descriptionYO-01027(Dibenzazepine,DBZ)
- Packaging50mg
- Price$561
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60310
- Product descriptionDibenzazepine(YO-01027)
- Packaging10mg
- Price$338
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD21523
- Product descriptionDBZ
- Packaging1mg
- Price$454.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD21523
- Product descriptionDBZ
- Packaging5mg
- Price$1501.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5291 | Deshydroxy LY-411575 | 10mg | $135 | 2021-12-16 | Buy |
| AK Scientific | X7602 | N-[(1s)-2-[[(7s)-6,7-dihydro-5-methyl-6-oxo-5h-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluro-benzeneacetamide | 1g | $6428 | 2021-12-16 | Buy |
| Alfa Aesar | J64904 | gamma-Secretase Inhibitor XX | 3mg | $761 | 2023-06-20 | Buy |
| Ambeed | A457173 | YO-01027 95+% | 2mg | $75 | 2021-12-16 | Buy |
| Ambeed | A457173 | YO-01027 95+% | 5mg | $135 | 2021-12-16 | Buy |
| Ambeed | A457173 | YO-01027 95+% | 10mg | $229 | 2021-12-16 | Buy |
| Ambeed | A457173 | YO-01027 95+% | 25mg | $388 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 10mM(in 1mL DMSO) | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 5mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 10mg | $185 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 25mg | $379 | 2021-12-16 | Buy |
| ApexBio Technology | A4018 | YO-01027(Dibenzazepine,DBZ) | 50mg | $561 | 2021-12-16 | Buy |
| Arctom | CFN60310 | Dibenzazepine(YO-01027) | 10mg | $338 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21523 | DBZ | 1mg | $454.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD21523 | DBZ | 5mg | $1501.5 | 2021-12-16 | Buy |
Properties
Melting point :257-259?C
Boiling point :801.3±65.0 °C(Predicted)
Density :1.35
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :White solid
pka :12.76±0.20(Predicted)
color :white to beige
InChIKey :QSHGISMANBKLQL-OWJWWREXSA-N
Boiling point :801.3±65.0 °C(Predicted)
Density :1.35
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :White solid
pka :12.76±0.20(Predicted)
color :white to beige
InChIKey :QSHGISMANBKLQL-OWJWWREXSA-N
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.More related product prices
471905-41-6 RO4929097 LY411575 DAPT Semagacestat FLI-06 γ-Secretase Inhibitor XXI GAMMA-SECRETASE INHIBITOR BETA-SECRETASE INHIBITOR IVRelated product price
- 471905-41-6
$28-2700 - RO4929097
$28-9435.2 - LY411575
$37-4023.9
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Hubei Jusheng Technology Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited
Nextpeptide Inc
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
